DENIS@home - Revision history

Admin at 04:48, 28 May 2026

2026-05-28T04:48:45Z

← Older revision		Revision as of 04:48, 28 May 2026
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	\| license = [[wikipedia:Apache License\|Apache License 2.0]]		\| license = [[wikipedia:Apache License\|Apache License 2.0]]
	}}		}}
	~~[[File:{{#setmainimage:DENIS@Home Logo.png}}\|alt=logo image\|center\|frameless]]~~
	[https://denis.usj.es/denisathome/ '''''DENIS@home'''''] is a '''''[[wikipedia:Volunteer computing\|volunteer distributed computing]]''''' project based on the [[wikipedia:Berkeley_Open_Infrastructure_for_Network_Computing\|BOINC]] middleware platform. The project is operated by the CoMBA (Computational Multiscale Biology and Medicine) research group at [[wikipedia:Universidad San Jorge\|Universidad San Jorge]] in Zaragoza, Spain, and focuses on large-scale simulations of cardiac electrophysiology and cardiovascular disease research.<ref>{{Cite web \|url=https://denis.usj.es/denisathome/ \|title=DENIS@home \|publisher=Universidad San Jorge \|access-date=2026-05-19}}</ref><ref>{{Cite journal \|last1=Monasterio \|first1=Violeta \|last2=Castro-Mur \|first2=Jesús \|last3=Carro \|first3=Jesús \|title=DENIS: Solving cardiac electrophysiological simulations with volunteer computing \|journal=PLoS ONE \|volume=13 \|issue=10 \|year=2018 \|pages=e0205568 \|doi=10.1371/journal.pone.0205568}}</ref>		[https://denis.usj.es/denisathome/ '''''DENIS@home'''''] is a '''''[[wikipedia:Volunteer computing\|volunteer distributed computing]]''''' project based on the [[wikipedia:Berkeley_Open_Infrastructure_for_Network_Computing\|BOINC]] middleware platform. The project is operated by the CoMBA (Computational Multiscale Biology and Medicine) research group at [[wikipedia:Universidad San Jorge\|Universidad San Jorge]] in Zaragoza, Spain, and focuses on large-scale simulations of cardiac electrophysiology and cardiovascular disease research.<ref>{{Cite web \|url=https://denis.usj.es/denisathome/ \|title=DENIS@home \|publisher=Universidad San Jorge \|access-date=2026-05-19}}</ref><ref>{{Cite journal \|last1=Monasterio \|first1=Violeta \|last2=Castro-Mur \|first2=Jesús \|last3=Carro \|first3=Jesús \|title=DENIS: Solving cardiac electrophysiological simulations with volunteer computing \|journal=PLoS ONE \|volume=13 \|issue=10 \|year=2018 \|pages=e0205568 \|doi=10.1371/journal.pone.0205568}}</ref>

Al Piskun at 15:56, 20 May 2026

2026-05-20T15:56:24Z

@@ Line 1: / Line 1: @@
-[[File:{{#setmainimage:DENIS@Home Logo.png}}|alt=logo image|center|frameless]]
+{{Infobox software
-{{Infobox software
+| website              = {{URL|https://denis.usj.es/denisathome/}}
-| name = DENIS@home
+| license              = [[wikipedia:Apache License|Apache License 2.0]]
 }}
+[[File:{{#setmainimage:DENIS@Home Logo.png}}|alt=logo image|center|frameless]]
 [https://denis.usj.es/denisathome/ '''''DENIS@home'''''] is a '''''[[wikipedia:Volunteer computing|volunteer distributed computing]]''''' project based on the [[wikipedia:Berkeley_Open_Infrastructure_for_Network_Computing|BOINC]] middleware platform. The project is operated by the CoMBA (Computational Multiscale Biology and Medicine) research group at [[wikipedia:Universidad San Jorge|Universidad San Jorge]] in Zaragoza, Spain, and focuses on large-scale simulations of cardiac electrophysiology and cardiovascular disease research.<ref>{{Cite web |url=https://denis.usj.es/denisathome/ |title=DENIS@home |publisher=Universidad San Jorge |access-date=2026-05-19}}</ref><ref>{{Cite journal |last1=Monasterio |first1=Violeta |last2=Castro-Mur |first2=Jesús |last3=Carro |first3=Jesús |title=DENIS: Solving cardiac electrophysiological simulations with volunteer computing |journal=PLoS ONE |volume=13 |issue=10 |year=2018 |pages=e0205568 |doi=10.1371/journal.pone.0205568}}</ref>
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 == References ==
-<references/>
+{{Reflist}}

Al Piskun at 18:22, 19 May 2026

2026-05-19T18:22:54Z

← Older revision		Revision as of 18:22, 19 May 2026
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	\| caption = DENIS@home application preferences interface		\| caption = DENIS@home application preferences interface
	\| developer = CoMBA Research Group, Universidad San Jorge		\| developer = CoMBA Research Group, Universidad San Jorge
	\| released = {{Start date and age\|2015\|3\|16}		\| released = {{Start date and age\|2015\|03\|16}}
	\| latest release version =		\| latest release version =
	\| latest release date =		\| latest release date =

Al Piskun at 18:20, 19 May 2026

2026-05-19T18:20:33Z

← Older revision		Revision as of 18:20, 19 May 2026
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	\| caption = DENIS@home application preferences interface		\| caption = DENIS@home application preferences interface
	\| developer = CoMBA Research Group, Universidad San Jorge		\| developer = CoMBA Research Group, Universidad San Jorge
	\| released = ~~2016~~		\| released = {{Start date and age\|2015\|3\|16}
	\| latest release version =		\| latest release version =
	\| latest release date =		\| latest release date =

Al Piskun: infobox and updates

2026-05-19T16:26:19Z

infobox and updates

Show changes

Al Piskun: /* In silico research */ reword

2024-02-11T22:27:53Z

In silico research: reword

← Older revision		Revision as of 22:27, 11 February 2024
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	==== <u>I</u>n silico research ====		==== <u>I</u>n silico research ====
	We could have asked you to use your heart, but we believe it is easier for you to give as your computer for a while. In Silico simulations of the electrical activity of the heart have become an indispensable technique to increase our knowledge of the heart behavior under normal or pathological conditions.		We could have asked you to use your heart, but we believe it is easier for you to give as your computer for a while. In Silico simulations of the electrical activity of the heart have become an indispensable technique to increase our knowledge of the heart behavior under normal or pathological conditions. DENIS wants to be a powerful tool for cardiology research.

	DENIS wants to be a powerful tool for ~~those all that make~~ research ~~in cardiology~~.

	==== <u>S</u>haring knowledge ====		==== <u>S</u>haring knowledge ====

Al Piskun: /* Goal */

2024-02-11T22:24:52Z

Goal

← Older revision		Revision as of 22:24, 11 February 2024
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	==== <u>N</u>etworking collaboration ====		==== <u>N</u>etworking collaboration ====
	DENIS connects volunteers with researchers to help them in their projects. No matter where you are. No matter where the project is. We want to connect you.		DENIS connects volunteers with researchers to help them in their projects. No matter where you are. No matter where the project is. We want to connect you. We don't only want to connect researchers and volunteers. We also want to connect researchers and help them to collaborate. We are currently working on it. Stay tuned, we will keep you informed.

	We don't only want to connect researchers and volunteers. We also want to connect researchers and help them to collaborate. We are currently working on it. Stay tuned, we will keep you informed.

	==== <u>I</u>n silico research ====		==== <u>I</u>n silico research ====
	We could have asked you to use your heart, but we believe it is easier for you to give as your computer for a while.		We could have asked you to use your heart, but we believe it is easier for you to give as your computer for a while. In Silico simulations of the electrical activity of the heart have become an indispensable technique to increase our knowledge of the heart behavior under normal or pathological conditions.

	In Silico simulations of the electrical activity of the heart have become an indispensable technique to increase our knowledge of the heart behavior under normal or pathological conditions.

	DENIS wants to be a powerful tool for those all that make research in cardiology.		DENIS wants to be a powerful tool for those all that make research in cardiology.

Al Piskun: /* Project team / Sponsors */ links

2024-02-11T22:17:38Z

Project team / Sponsors: links

← Older revision		Revision as of 22:17, 11 February 2024
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	== Project team / Sponsors ==		== Project team / Sponsors ==
	Jesús Carro. Violeta Monasterio. Alejandro Alcaine. Marta Gómez.		The members of the research group participating in this project are: Jesús Carro. Violeta Monasterio. Alejandro Alcaine. Marta Gómez.

	Universidad San Jorge.		DENIS@home is developed and maintained by the [https://www.usj.es/investigacion/grupos-investigacion/CoMBA '''''CoMBA research group'''''] at [https://www.usj.es/ '''''Universidad San Jorge'''''].

	== Scientific results ==		== Scientific results ==

Al Piskun: /* Goal */ clarify

2024-02-11T22:07:52Z

Goal: clarify

← Older revision		Revision as of 22:07, 11 February 2024
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	* <u>'''S'''</u>haring knowledge		* <u>'''S'''</u>haring knowledge

	==== ~~Distributed~~ computing ====		==== <u>D</u>istributed computing ====
	DENIS uses volunteer devices to compute large amounts of cardiac electrophysiological simulations. DENIS uses the idle time on your computer (Windows , Linux or Mac) to simulate the electrical activity of the heart.		DENIS uses volunteer devices to compute large amounts of cardiac electrophysiological simulations. DENIS uses the idle time on your computer (Windows , Linux or Mac) to simulate the electrical activity of the heart.

	DENIS works over the [[wikipedia:Berkeley_Open_Infrastructure_for_Network_Computing\|'''''Berkeley Open Infrastructure for Network Computing (BOINC)''''']]. BOINC is an open source middleware system developed at the University of Berkeley.		DENIS works over the [[wikipedia:Berkeley_Open_Infrastructure_for_Network_Computing\|'''''Berkeley Open Infrastructure for Network Computing (BOINC)''''']]. BOINC is an open source middleware system developed at the University of Berkeley.

	==== ~~Electrophysiological~~ models ====		==== <u>E</u>lectrophysiological models ====
	DENIS has been created to help researchers to compute very large groups of cardiac electrophysiological model variations. Cardiac electrophysiological models are mathematical representations of the electrical activity of the cardiac cells.		DENIS has been created to help researchers to compute very large groups of cardiac electrophysiological model variations. Cardiac electrophysiological models are mathematical representations of the electrical activity of the cardiac cells.

	Models used in DENIS are described using the CellML language to facilitate other researchers to include their models in DENIS. CellML is an open standard based on the XML markup language. CellML is being developed by the Auckland Bioengineering Institute at the University of Auckland and affiliated research groups.		Models used in DENIS are described using the CellML language to facilitate other researchers to include their models in DENIS. CellML is an open standard based on the XML markup language. CellML is being developed by the Auckland Bioengineering Institute at the University of Auckland and affiliated research groups.

	==== ~~Networking~~ collaboration ====		==== <u>N</u>etworking collaboration ====
	DENIS connects volunteers with researchers to help them in their projects. No matter where you are. No matter where the project is. We want to connect you.		DENIS connects volunteers with researchers to help them in their projects. No matter where you are. No matter where the project is. We want to connect you.

	We don't only want to connect researchers and volunteers. We also want to connect researchers and help them to collaborate. We are currently working on it. Stay tuned, we will keep you informed.		We don't only want to connect researchers and volunteers. We also want to connect researchers and help them to collaborate. We are currently working on it. Stay tuned, we will keep you informed.

	==== In silico research ====		==== <u>I</u>n silico research ====
	We could have asked you to use your heart, but we believe it is easier for you to give as your computer for a while.		We could have asked you to use your heart, but we believe it is easier for you to give as your computer for a while.

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	DENIS wants to be a powerful tool for those all that make research in cardiology.		DENIS wants to be a powerful tool for those all that make research in cardiology.

	==== ~~Sharing~~ knowledge ====		==== <u>S</u>haring knowledge ====
	DENIS works because the volunteers share their computational capacity with us. For this reason, all the researchers that use DENIS must share their results and all the people must be able to know what is running in its computer: All the results obtained using DENIS must be published. All the models used in DENIS must be shared once the project has finished.		DENIS works because the volunteers share their computational capacity with us. For this reason, all the researchers that use DENIS must share their results and all the people must be able to know what is running in its computer: All the results obtained using DENIS must be published. All the models used in DENIS must be shared once the project has finished.

Al Piskun: information

2024-02-11T22:02:49Z

information

← Older revision		Revision as of 22:02, 11 February 2024
Line 13:		Line 13:
	* <u>'''I'''</u>n silico research		* <u>'''I'''</u>n silico research
	* <u>'''S'''</u>haring knowledge		* <u>'''S'''</u>haring knowledge

			==== Distributed computing ====
			DENIS uses volunteer devices to compute large amounts of cardiac electrophysiological simulations. DENIS uses the idle time on your computer (Windows , Linux or Mac) to simulate the electrical activity of the heart.

			DENIS works over the [[wikipedia:Berkeley_Open_Infrastructure_for_Network_Computing\|'''''Berkeley Open Infrastructure for Network Computing (BOINC)''''']]. BOINC is an open source middleware system developed at the University of Berkeley.

			==== Electrophysiological models ====
			DENIS has been created to help researchers to compute very large groups of cardiac electrophysiological model variations. Cardiac electrophysiological models are mathematical representations of the electrical activity of the cardiac cells.

			Models used in DENIS are described using the CellML language to facilitate other researchers to include their models in DENIS. CellML is an open standard based on the XML markup language. CellML is being developed by the Auckland Bioengineering Institute at the University of Auckland and affiliated research groups.

			==== Networking collaboration ====
			DENIS connects volunteers with researchers to help them in their projects. No matter where you are. No matter where the project is. We want to connect you.

			We don't only want to connect researchers and volunteers. We also want to connect researchers and help them to collaborate. We are currently working on it. Stay tuned, we will keep you informed.

			==== In silico research ====
			We could have asked you to use your heart, but we believe it is easier for you to give as your computer for a while.

			In Silico simulations of the electrical activity of the heart have become an indispensable technique to increase our knowledge of the heart behavior under normal or pathological conditions.

			DENIS wants to be a powerful tool for those all that make research in cardiology.

			==== Sharing knowledge ====
			DENIS works because the volunteers share their computational capacity with us. For this reason, all the researchers that use DENIS must share their results and all the people must be able to know what is running in its computer: All the results obtained using DENIS must be published. All the models used in DENIS must be shared once the project has finished.

	== Methods ==		== Methods ==
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	[[wikipedia:Electrophysiology\|'''''Electrophysiological''''']] models are a powerful tool to study the electrical activity of cardiac cells under normal or pathological conditions and can also help predict the effects of drugs in the heart. Because these models are complex, it's necessary to simulate them many times (varying the conditions or model parameters). For this reason, researchers in this field usually require high computational power and BOINC is the perfect solution to distribute the work to volunteer computers and achieve that high computational power.		[[wikipedia:Electrophysiology\|'''''Electrophysiological''''']] models are a powerful tool to study the electrical activity of cardiac cells under normal or pathological conditions and can also help predict the effects of drugs in the heart. Because these models are complex, it's necessary to simulate them many times (varying the conditions or model parameters). For this reason, researchers in this field usually require high computational power and BOINC is the perfect solution to distribute the work to volunteer computers and achieve that high computational power.

			All the programs developed for the DENIS project are under the '''''[https://www.apache.org/licenses/LICENSE-2.0 Apache License V2]''''' and are available in [https://bitbucket.org/comba_usj/workspace/projects/DENIS '''''our Bitbucket repository'''''].

	== Project team / Sponsors ==		== Project team / Sponsors ==
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	== Scientific publications ==		== Scientific publications ==

	Research results from DENIS@home		==== Research results from DENIS@home ====
	# J. Carro (2019). [https://zaguan.unizar.es/record/78866 ''New Methodologies for the Development and Validation of Electrophysiological Models''. PhD Thesis (2019)].		# J. Carro (2019). [https://zaguan.unizar.es/record/78866 ''New Methodologies for the Development and Validation of Electrophysiological Models''. PhD Thesis (2019)].
	# J. Carro, J.F. Rodríguez-Matas, E. Pueyo (2017). ''[https://doi.org/10.1016/j.bpj.2016.11.2183 A Methodology to Improve Human Ventricular Models for the Investigation of Cardiac Arrhythmias]''. Biophysical Journal. DOI: 10.1016/j.bpj.2016.11.2183.		# J. Carro, J.F. Rodríguez-Matas, E. Pueyo (2017). ''[https://doi.org/10.1016/j.bpj.2016.11.2183 A Methodology to Improve Human Ventricular Models for the Investigation of Cardiac Arrhythmias]''. Biophysical Journal. DOI: 10.1016/j.bpj.2016.11.2183.

	Research results using DENIS@home software		==== Research results using DENIS@home software ====
	# M. Gomez, J. Carro, E. Pueyo, V. Monasterio (2022) ''[http://doi.org/10.22489/CinC.2022.228 An in Silico Investigation into the Role of SK Channels in Failing Ventricular Myocytes]''. Proceedings of the XLVIII International Conference on Computing in Cardiology. Tampere, Finland DOI: 10.22489/CinC.2022.228.		# M. Gomez, J. Carro, E. Pueyo, V. Monasterio (2022) ''[http://doi.org/10.22489/CinC.2022.228 An in Silico Investigation into the Role of SK Channels in Failing Ventricular Myocytes]''. Proceedings of the XLVIII International Conference on Computing in Cardiology. Tampere, Finland DOI: 10.22489/CinC.2022.228.
	# M. Gomez, J. Carro, V. Monasterio, E. Pueyo (2022). ''[https://papiro.unizar.es/ojs/index.php/jji3a/article/view/7021/5804 Investigación in silico sobre el papel de los canales SK en miocitos ventriculares de pacientes con insuficiencia cardiaca]''. Jornada de Jóvenes Investigadores e Investigadoras del I3A (ISSN:2341-4790) Vol. 10 (2022): Actas de la XI Jornada de Jóvenes Investigadores e Investigadoras del I3A - 16 de junio de 2022. DOI: 10.26754/jjii3a.20227021.		# M. Gomez, J. Carro, V. Monasterio, E. Pueyo (2022). ''[https://papiro.unizar.es/ojs/index.php/jji3a/article/view/7021/5804 Investigación in silico sobre el papel de los canales SK en miocitos ventriculares de pacientes con insuficiencia cardiaca]''. Jornada de Jóvenes Investigadores e Investigadoras del I3A (ISSN:2341-4790) Vol. 10 (2022): Actas de la XI Jornada de Jóvenes Investigadores e Investigadoras del I3A - 16 de junio de 2022. DOI: 10.26754/jjii3a.20227021.
	# M. Gómez, J. Carro, E. Pueyo, V. Monasterio (2021) ''[https://seib.org.es/descarga/libro-de-actas-caseib-2021/?wpdmdl=3382 Modificación de un modelo de miocito ventricular humano para representar el papel de los canales SK en insuficiencia cardiaca]''. XXXIX Congreso de la Sociedad Española de Ingeniería Biomédica CASEIB. Madrid, España.		# M. Gómez, J. Carro, E. Pueyo, V. Monasterio (2021) ''[https://seib.org.es/descarga/libro-de-actas-caseib-2021/?wpdmdl=3382 Modificación de un modelo de miocito ventricular humano para representar el papel de los canales SK en insuficiencia cardiaca]''. XXXIX Congreso de la Sociedad Española de Ingeniería Biomédica CASEIB. Madrid, España.

	Publications about DENIS@home		==== Publications about DENIS@home ====
	# V. Monasterio, J. Castro-Mur, J. Carro (2018). ''[https://doi.org/10.1371/journal.pone.0205568 DENIS: Solving cardiac electrophysiological simulations with volunteer computing]''. PLoS ONE 13(10): e0205568. DOI: 10.1371/journal.pone.0205568.		# V. Monasterio, J. Castro-Mur, J. Carro (2018). ''[https://doi.org/10.1371/journal.pone.0205568 DENIS: Solving cardiac electrophysiological simulations with volunteer computing]''. PLoS ONE 13(10): e0205568. DOI: 10.1371/journal.pone.0205568.
	# J. Castro-Mur, V. Monasterio, J. Carro (2016). ''[https://doi.org/10.1109/WETICE.2016.34 Volunteer Computing Approach for the Collaborative Simulation of Electrophysiological Models]''. IEEE 25th International Conference on Enabling Technologies: Infrastructure for Collaborative Enterprises (WETICE), Paris, France, 2016, pp. 118-123, DOI: 10.1109/WETICE.2016.34.		# J. Castro-Mur, V. Monasterio, J. Carro (2016). ''[https://doi.org/10.1109/WETICE.2016.34 Volunteer Computing Approach for the Collaborative Simulation of Electrophysiological Models]''. IEEE 25th International Conference on Enabling Technologies: Infrastructure for Collaborative Enterprises (WETICE), Paris, France, 2016, pp. 118-123, DOI: 10.1109/WETICE.2016.34.