Proteins@home: Difference between revisions

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{{Infobox software

| name = ~~Proteins~~@home

| name = proteins@home

| screenshot = Proteins.gif

| caption = The ~~Proteins~~@home screensaver, visualising a rotating protein structure

| caption = The proteins@home screensaver, visualising a rotating protein structure

| description = ~~Proteins~~@home was a completed Biochemistry BOINC project that tackled the inverse protein folding problem, operated by the Laboratoire de Biochimie at École Polytechnique, Palaiseau, France, from December 2006 to June 2008.

| description = proteins@home was a completed Biochemistry BOINC project that tackled the inverse protein folding problem, operated by the Laboratoire de Biochimie at École Polytechnique, Palaiseau, France, from December 2006 to June 2008.

| status = Completed

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}}

'''~~Proteins~~@home''' ~~(styled ''proteins@home'')~~ was a non-profit [[volunteer computing]] project built on the [[Berkeley Open Infrastructure for Network Computing]] (BOINC) platform.<ref name="wikipedia">{{cite encyclopedia |title=Proteins@home |encyclopedia=Wikipedia |url=https://en.wikipedia.org/wiki/Proteins@home |access-date=2026-06-08}}</ref> The project ran from December 28, 2006 to June 2008 and was operated by the Laboratoire de Biochimie (CNRS UMR 7654) in the Department of Biology at [[École Polytechnique]], located in Palaiseau, near Paris, France.<ref name="boinc-news">{{cite web |url=https://boinc.berkeley.edu/forum_thread.php?id=5136 |title=The Proteins@Home project is now open |publisher=BOINC Message Boards |date=2006-12-28 |access-date=2026-06-08}}</ref> Its scientific goal was to map the ''inverse protein folding problem'' across approximately 1,500 representative [[protein fold|protein folds]], building a database of pairwise energy functions that could be used to predict protein structure, understand protein evolution, and design new proteins with potential biomedical applications.<ref name="projdescription">{{cite web |url=https://web.archive.org/web/20070601000000*/http://biology.polytechnique.fr/proteinsathome/ |title=proteins@home |publisher=Wayback Machine |access-date=2026-06-08}}</ref>

'''[https://web.archive.org/web/20070306022756/http://biology.polytechnique.fr/proteinsathome/ proteins@home]''' was a non-profit [[volunteer computing]] project built on the [[Berkeley Open Infrastructure for Network Computing]] (BOINC) platform.<ref name="wikipedia">{{cite encyclopedia |title=Proteins@home |encyclopedia=Wikipedia |url=https://en.wikipedia.org/wiki/Proteins@home |access-date=2026-06-08}}</ref> The project ran from December 28, 2006 to June 2008 and was operated by the Laboratoire de Biochimie (CNRS UMR 7654) in the Department of Biology at [[École Polytechnique]], located in Palaiseau, near Paris, France.<ref name="boinc-news">{{cite web |url=https://boinc.berkeley.edu/forum_thread.php?id=5136 |title=The Proteins@Home project is now open |publisher=BOINC Message Boards |date=2006-12-28 |access-date=2026-06-08}}</ref> Its scientific goal was to map the ''inverse protein folding problem'' across approximately 1,500 representative [[protein fold|protein folds]], building a database of pairwise energy functions that could be used to predict protein structure, understand protein evolution, and design new proteins with potential biomedical applications.<ref name="projdescription">{{cite web |url=https://web.archive.org/web/20070601000000*/http://biology.polytechnique.fr/proteinsathome/ |title=proteins@home |publisher=Wayback Machine |access-date=2026-06-08}}</ref>

== Background ==

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== Project description ==

[[File:Ecole Polytechnique France seen from lake DSC03389.JPG|thumb|250px|left|The campus of [[École Polytechnique]] at Palaiseau, France, home of the Laboratoire de Biochimie (CNRS UMR 7654) that ran proteins@home.<ref>{{cite web |url=https://commons.wikimedia.org/wiki/File:Ecole_Polytechnique_France_seen_from_lake_DSC03389.JPG |title=File:Ecole Polytechnique France seen from lake DSC03389.JPG |publisher=Wikimedia Commons |access-date=2026-06-08}}</ref>]]

=== Launch and operation ===

[[File:Ecole Polytechnique France seen from lake DSC03389.JPG|thumb|250px|left|The campus of [[École Polytechnique]] at Palaiseau, France, home of the Laboratoire de Biochimie (CNRS UMR 7654) that ran Proteins@home.<ref>{{cite web |url=https://commons.wikimedia.org/wiki/File:Ecole_Polytechnique_France_seen_from_lake_DSC03389.JPG |title=File:Ecole Polytechnique France seen from lake DSC03389.JPG |publisher=Wikimedia Commons |access-date=2026-06-08}}</ref>]]

proteins@home was formally announced as open on December 28, 2006, when BOINC project administrator David Anderson posted on the BOINC message boards that the project was "now open" and "based at the École Polytechnique in Paris."<ref name="boinc-news"/> Volunteers could register and download the BOINC client to begin donating CPU cycles to the project.

~~Proteins~~@home was formally announced as open on December 28, 2006, when BOINC project administrator David Anderson posted on the BOINC message boards that the project was "now open" and "based at the École Polytechnique in Paris."<ref name="boinc-news"/> Volunteers could register and download the BOINC client to begin donating CPU cycles to the project.

The research team was led by '''Thomas Simonson''', with contributions from '''Marcel Schmidt am Busch''', '''Anne Lopes''', '''David Mignon''', '''Thomas Gaillard''', '''Najette Amara''', and '''Christine Bathelt''', all based at the Laboratoire de Biochimie (CNRS UMR 7654), Department of Biology, École Polytechnique, 91128 Palaiseau, France.<ref name="bmc2008">{{cite journal |last1=Schmidt am Busch |first1=Marcel |last2=Lopes |first2=Anne |last3=Amara |first3=Najette |last4=Bathelt |first4=Christine |last5=Simonson |first5=Thomas |date=2008-03-13 |title=Testing the Coulomb/Accessible Surface Area solvent model for protein stability, ligand binding, and protein design |journal=BMC Bioinformatics |volume=9 |page=148 |doi=10.1186/1471-2105-9-148 |pmid=18366628 |pmc=2292695}}</ref><ref name="proteus">{{cite web |url=https://proteus.polytechnique.fr/ |title=The Proteus software for computational protein design |publisher=École Polytechnique |access-date=2026-06-08}}</ref>

The BOINC news feed recorded on February 7, 2008 that "~~Proteins~~@Home has resumed operations",<ref name="boinc-newsfeed">{{cite web |url=https://github.com/BOINC/boinc-site/blob/master/boinc_news.php |title=boinc_news.php (BOINC site source) |publisher=GitHub / BOINC |access-date=2026-06-08}}</ref> indicating a temporary interruption before the project reopened to participants. The project concluded in June 2008.

The BOINC news feed recorded on February 7, 2008 that "proteins@Home has resumed operations",<ref name="boinc-newsfeed">{{cite web |url=https://github.com/BOINC/boinc-site/blob/master/boinc_news.php |title=boinc_news.php (BOINC site source) |publisher=GitHub / BOINC |access-date=2026-06-08}}</ref> indicating a temporary interruption before the project reopened to participants. The project concluded in June 2008.

During its operational period, the ~~Proteins~~@home distributed computing platform was used by volunteers in over 100 countries.<ref name="plosone2010">{{cite journal |last1=Schmidt am Busch |first1=Marcel |last2=Sedano |first2=Audrey |last3=Simonson |first3=Thomas |date=2010-05-05 |title=Computational Protein Design: Validation and Possible Relevance as a Tool for Homology Searching and Fold Recognition |journal=PLOS ONE |volume=5 |issue=5 |page=e10410 |doi=10.1371/journal.pone.0010410 |pmid=20463972 |pmc=2864755}}</ref>

During its operational period, the proteins@home distributed computing platform was used by volunteers in over 100 countries.<ref name="plosone2010">{{cite journal |last1=Schmidt am Busch |first1=Marcel |last2=Sedano |first2=Audrey |last3=Simonson |first3=Thomas |date=2010-05-05 |title=Computational Protein Design: Validation and Possible Relevance as a Tool for Homology Searching and Fold Recognition |journal=PLOS ONE |volume=5 |issue=5 |page=e10410 |doi=10.1371/journal.pone.0010410 |pmid=20463972 |pmc=2864755}}</ref>

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* [https://web.archive.org/web/20080101000000*/http://biology.polytechnique.fr/proteinsathome/ Proteins@home official website (Wayback Machine)]

* [https://boinc.berkeley.edu/wiki/Proteins@Home Proteins@Home] at the BOINC wiki

* [https://proteus.polytechnique.fr/ Proteus] successor software package, École Polytechnique

* [https://proteus.polytechnique.fr/ Proteus] — successor software package, École Polytechnique

* [https://commons.wikimedia.org/wiki/Category:Proteins@home Proteins@home] at Wikimedia Commons

* [https://boinc.berkeley.edu/pubs.php Publications by BOINC Projects] at boinc.berkeley.edu

@@ Line 1: / Line 1: @@
 {{Infobox software
-| name                 = Proteins@home
+| name                 = proteins@home
 | screenshot           = Proteins.gif
-| caption              = The Proteins@home screensaver, visualising a rotating protein structure
+| caption              = The proteins@home screensaver, visualising a rotating protein structure
-| description          = Proteins@home was a completed Biochemistry BOINC project that tackled the inverse protein folding problem, operated by the Laboratoire de Biochimie at École Polytechnique, Palaiseau, France, from December 2006 to June 2008.
+| description          = proteins@home was a completed Biochemistry BOINC project that tackled the inverse protein folding problem, operated by the Laboratoire de Biochimie at École Polytechnique, Palaiseau, France, from December 2006 to June 2008.
 | status               = Completed
@@ Line 21: / Line 21: @@
 }}
-'''Proteins@home''' (styled ''proteins@home'') was a non-profit [[volunteer computing]] project built on the [[Berkeley Open Infrastructure for Network Computing]] (BOINC) platform.<ref name="wikipedia">{{cite encyclopedia |title=Proteins@home |encyclopedia=Wikipedia |url=https://en.wikipedia.org/wiki/Proteins@home |access-date=2026-06-08}}</ref> The project ran from December 28, 2006 to June 2008 and was operated by the Laboratoire de Biochimie (CNRS UMR&nbsp;7654) in the Department of Biology at [[École Polytechnique]], located in Palaiseau, near Paris, France.<ref name="boinc-news">{{cite web |url=https://boinc.berkeley.edu/forum_thread.php?id=5136 |title=The Proteins@Home project is now open |publisher=BOINC Message Boards |date=2006-12-28 |access-date=2026-06-08}}</ref> Its scientific goal was to map the ''inverse protein folding problem'' across approximately 1,500 representative [[protein fold|protein folds]], building a database of pairwise energy functions that could be used to predict protein structure, understand protein evolution, and design new proteins with potential biomedical applications.<ref name="projdescription">{{cite web |url=https://web.archive.org/web/20070601000000*/http://biology.polytechnique.fr/proteinsathome/ |title=proteins@home |publisher=Wayback Machine |access-date=2026-06-08}}</ref>
+{{Lowercase title}}
+'''[https://web.archive.org/web/20070306022756/http://biology.polytechnique.fr/proteinsathome/ proteins@home]''' was a non-profit [[volunteer computing]] project built on the [[Berkeley Open Infrastructure for Network Computing]] (BOINC) platform.<ref name="wikipedia">{{cite encyclopedia |title=Proteins@home |encyclopedia=Wikipedia |url=https://en.wikipedia.org/wiki/Proteins@home |access-date=2026-06-08}}</ref> The project ran from December 28, 2006 to June 2008 and was operated by the Laboratoire de Biochimie (CNRS UMR&nbsp;7654) in the Department of Biology at [[École Polytechnique]], located in Palaiseau, near Paris, France.<ref name="boinc-news">{{cite web |url=https://boinc.berkeley.edu/forum_thread.php?id=5136 |title=The Proteins@Home project is now open |publisher=BOINC Message Boards |date=2006-12-28 |access-date=2026-06-08}}</ref> Its scientific goal was to map the ''inverse protein folding problem'' across approximately 1,500 representative [[protein fold|protein folds]], building a database of pairwise energy functions that could be used to predict protein structure, understand protein evolution, and design new proteins with potential biomedical applications.<ref name="projdescription">{{cite web |url=https://web.archive.org/web/20070601000000*/http://biology.polytechnique.fr/proteinsathome/ |title=proteins@home |publisher=Wayback Machine |access-date=2026-06-08}}</ref>
 == Background ==
@@ Line 38: / Line 40: @@
 == Project description ==
+[[File:Ecole Polytechnique France seen from lake DSC03389.JPG|thumb|250px|left|The campus of [[École Polytechnique]] at Palaiseau, France, home of the Laboratoire de Biochimie (CNRS UMR 7654) that ran proteins@home.<ref>{{cite web |url=https://commons.wikimedia.org/wiki/File:Ecole_Polytechnique_France_seen_from_lake_DSC03389.JPG |title=File:Ecole Polytechnique France seen from lake DSC03389.JPG |publisher=Wikimedia Commons |access-date=2026-06-08}}</ref>]]
 === Launch and operation ===
-[[File:Ecole Polytechnique France seen from lake DSC03389.JPG|thumb|250px|left|The campus of [[École Polytechnique]] at Palaiseau, France, home of the Laboratoire de Biochimie (CNRS UMR 7654) that ran Proteins@home.<ref>{{cite web |url=https://commons.wikimedia.org/wiki/File:Ecole_Polytechnique_France_seen_from_lake_DSC03389.JPG |title=File:Ecole Polytechnique France seen from lake DSC03389.JPG |publisher=Wikimedia Commons |access-date=2026-06-08}}</ref>]]
+proteins@home was formally announced as open on December 28, 2006, when BOINC project administrator David Anderson posted on the BOINC message boards that the project was "now open" and "based at the École Polytechnique in Paris."<ref name="boinc-news"/> Volunteers could register and download the BOINC client to begin donating CPU cycles to the project.
-Proteins@home was formally announced as open on December 28, 2006, when BOINC project administrator David Anderson posted on the BOINC message boards that the project was "now open" and "based at the École Polytechnique in Paris."<ref name="boinc-news"/> Volunteers could register and download the BOINC client to begin donating CPU cycles to the project.
 The research team was led by '''Thomas Simonson''', with contributions from '''Marcel Schmidt am Busch''', '''Anne Lopes''', '''David Mignon''', '''Thomas Gaillard''', '''Najette Amara''', and '''Christine Bathelt''', all based at the Laboratoire de Biochimie (CNRS UMR&nbsp;7654), Department of Biology, École Polytechnique, 91128 Palaiseau, France.<ref name="bmc2008">{{cite journal |last1=Schmidt am Busch |first1=Marcel |last2=Lopes |first2=Anne |last3=Amara |first3=Najette |last4=Bathelt |first4=Christine |last5=Simonson |first5=Thomas |date=2008-03-13 |title=Testing the Coulomb/Accessible Surface Area solvent model for protein stability, ligand binding, and protein design |journal=BMC Bioinformatics |volume=9 |page=148 |doi=10.1186/1471-2105-9-148 |pmid=18366628 |pmc=2292695}}</ref><ref name="proteus">{{cite web |url=https://proteus.polytechnique.fr/ |title=The Proteus software for computational protein design |publisher=École Polytechnique |access-date=2026-06-08}}</ref>
-The BOINC news feed recorded on February 7, 2008 that "Proteins@Home has resumed operations",<ref name="boinc-newsfeed">{{cite web |url=https://github.com/BOINC/boinc-site/blob/master/boinc_news.php |title=boinc_news.php (BOINC site source) |publisher=GitHub / BOINC |access-date=2026-06-08}}</ref> indicating a temporary interruption before the project reopened to participants. The project concluded in June 2008.
+The BOINC news feed recorded on February 7, 2008 that "proteins@Home has resumed operations",<ref name="boinc-newsfeed">{{cite web |url=https://github.com/BOINC/boinc-site/blob/master/boinc_news.php |title=boinc_news.php (BOINC site source) |publisher=GitHub / BOINC |access-date=2026-06-08}}</ref> indicating a temporary interruption before the project reopened to participants. The project concluded in June 2008.
-During its operational period, the Proteins@home distributed computing platform was used by volunteers in over 100 countries.<ref name="plosone2010">{{cite journal |last1=Schmidt am Busch |first1=Marcel |last2=Sedano |first2=Audrey |last3=Simonson |first3=Thomas |date=2010-05-05 |title=Computational Protein Design: Validation and Possible Relevance as a Tool for Homology Searching and Fold Recognition |journal=PLOS ONE |volume=5 |issue=5 |page=e10410 |doi=10.1371/journal.pone.0010410 |pmid=20463972 |pmc=2864755}}</ref>
+During its operational period, the proteins@home distributed computing platform was used by volunteers in over 100 countries.<ref name="plosone2010">{{cite journal |last1=Schmidt am Busch |first1=Marcel |last2=Sedano |first2=Audrey |last3=Simonson |first3=Thomas |date=2010-05-05 |title=Computational Protein Design: Validation and Possible Relevance as a Tool for Homology Searching and Fold Recognition |journal=PLOS ONE |volume=5 |issue=5 |page=e10410 |doi=10.1371/journal.pone.0010410 |pmid=20463972 |pmc=2864755}}</ref>
@@ Line 118: / Line 120: @@
 * [https://web.archive.org/web/20080101000000*/http://biology.polytechnique.fr/proteinsathome/ Proteins@home official website (Wayback Machine)]
-* [https://boinc.berkeley.edu/wiki/Proteins@Home Proteins@Home] at the BOINC wiki
+* [https://proteus.polytechnique.fr/ Proteus]  successor software package, École Polytechnique
-* [https://proteus.polytechnique.fr/ Proteus] — successor software package, École Polytechnique
 * [https://commons.wikimedia.org/wiki/Category:Proteins@home Proteins@home] at Wikimedia Commons
 * [https://boinc.berkeley.edu/pubs.php Publications by BOINC Projects] at boinc.berkeley.edu