POEM@HOME: Difference between revisions
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'''POEM@HOME''' (also written '''POEM@Home''') was a [[wikipedia:volunteer computing|volunteer computing]] project running on the [[wikipedia:Berkeley Open Infrastructure for Network Computing|Berkeley Open Infrastructure for Network Computing (BOINC)]] platform.<ref name="wp-newsarchive">{{Cite web |url=http://boinc.fzk.de/poem/old_news.php |title=News archive |website=boinc.fzk.de |publisher=Karlsruhe Institute of Technology |archive-url=https://web.archive.org/web/20140224005936/http://boinc.fzk.de/poem/old_news.php |archive-date=2014-02-24 |url-status=dead |access-date=2026-07-18}}</ref><ref name="end-announcement">{{Cite web |url=http://boinc.fzk.de/poem/forum_thread.php?id=1280 |title=The Future of POEM@HOME |website=boinc.fzk.de |publisher=Karlsruhe Institute of Technology |date=2016-10-04 |archive-url=https://web.archive.org/web/20161009200537/http://boinc.fzk.de/poem/forum_thread.php?id=1280 |archive-date=2016-10-09 |url-status=dead |access-date=2026-07-18}}</ref> The project was hosted by the [[wikipedia:Karlsruhe Institute of Technology|Karlsruhe Institute of Technology (KIT)]], specifically the Institute of Nanotechnology (INT), in the research group of Prof. Dr. Wolfgang Wenzel.<ref name="strunk-bio">{{Cite web |url=http://www.timo-strunk.de/?page_id=4 |title=About Me |website=timo-strunk.de |author=Strunk, Timo |access-date=2026-07-18}}</ref> POEM@HOME used [[wikipedia:volunteer computing|volunteers']] idle computer time to simulate [[wikipedia:protein folding|protein folding]] and predict [[wikipedia:protein structure prediction|protein structure]] from [[wikipedia:amino acid|amino acid]] sequence, based on [[wikipedia:Anfinsen's dogma|Anfinsen's dogma]], the hypothesis that a protein's biologically active, native conformation corresponds to the global minimum of its [[wikipedia:Gibbs free energy|free energy]] landscape.<ref name="wp-newsarchive" /><ref name="verma-pff02">{{Cite journal |authors=Verma, A., Wenzel, W. |title=A Free-Energy Approach for All-Atom Protein Simulation |journal=Biophysical Journal |volume=96 |issue=9 |pages=3483-3494 |date=2009 |doi=10.1016/j.bpj.2008.12.3921}}</ref> The project ran from 2007 until it was formally retired in October 2016, after advances in GPU-accelerated simulation reduced its need for volunteered CPU time.<ref name="wp-newsarchive" /><ref name="end-announcement" /> | '''[https://web.archive.org/http://boinc.fzk.de/poem/ POEM@HOME]''' (also written '''POEM@Home''') was a [[wikipedia:volunteer computing|volunteer computing]] project running on the [[wikipedia:Berkeley Open Infrastructure for Network Computing|Berkeley Open Infrastructure for Network Computing (BOINC)]] platform.<ref name="wp-newsarchive">{{Cite web |url=http://boinc.fzk.de/poem/old_news.php |title=News archive |website=boinc.fzk.de |publisher=Karlsruhe Institute of Technology |archive-url=https://web.archive.org/web/20140224005936/http://boinc.fzk.de/poem/old_news.php |archive-date=2014-02-24 |url-status=dead |access-date=2026-07-18}}</ref><ref name="end-announcement">{{Cite web |url=http://boinc.fzk.de/poem/forum_thread.php?id=1280 |title=The Future of POEM@HOME |website=boinc.fzk.de |publisher=Karlsruhe Institute of Technology |date=2016-10-04 |archive-url=https://web.archive.org/web/20161009200537/http://boinc.fzk.de/poem/forum_thread.php?id=1280 |archive-date=2016-10-09 |url-status=dead |access-date=2026-07-18}}</ref> The project was hosted by the [[wikipedia:Karlsruhe Institute of Technology|Karlsruhe Institute of Technology (KIT)]], specifically the Institute of Nanotechnology (INT), in the research group of Prof. Dr. Wolfgang Wenzel.<ref name="strunk-bio">{{Cite web |url=http://www.timo-strunk.de/?page_id=4 |title=About Me |website=timo-strunk.de |author=Strunk, Timo |access-date=2026-07-18}}</ref> POEM@HOME used [[wikipedia:volunteer computing|volunteers']] idle computer time to simulate [[wikipedia:protein folding|protein folding]] and predict [[wikipedia:protein structure prediction|protein structure]] from [[wikipedia:amino acid|amino acid]] sequence, based on [[wikipedia:Anfinsen's dogma|Anfinsen's dogma]], the hypothesis that a protein's biologically active, native conformation corresponds to the global minimum of its [[wikipedia:Gibbs free energy|free energy]] landscape.<ref name="wp-newsarchive" /><ref name="verma-pff02">{{Cite journal |authors=Verma, A., Wenzel, W. |title=A Free-Energy Approach for All-Atom Protein Simulation |journal=Biophysical Journal |volume=96 |issue=9 |pages=3483-3494 |date=2009 |doi=10.1016/j.bpj.2008.12.3921}}</ref> The project ran from 2007 until it was formally retired in October 2016, after advances in GPU-accelerated simulation reduced its need for volunteered CPU time.<ref name="wp-newsarchive" /><ref name="end-announcement" /> | ||
The POEM@HOME client applications were proprietary and were not released as open-source software.<ref name="wp-newsarchive" /> | The POEM@HOME client applications were proprietary and were not released as open-source software.<ref name="wp-newsarchive" /> | ||