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== Scientific Publications ==
== Publications ==
=== Papers using BOINC-computed data ===


World Community Grid research teams have produced over 50 peer-reviewed scientific publications in journals including ''PLOS Neglected Tropical Diseases'', ''Cancer Medicine'', and others.<ref name="wcg-submit">{{cite web |url=https://www.worldcommunitygrid.org/research/viewSubmitAProposal.do |title=Submit a Proposal |publisher=World Community Grid |access-date=2026-05-25}}</ref> A curated list of papers arising from BOINC-based computing — including World Community Grid — is maintained by BOINC at Berkeley.<ref name="boinc-pubs">{{cite web |url=https://boinc.berkeley.edu/pubs.php |title=Publications by BOINC Projects |publisher=BOINC / UC Berkeley |access-date=2026-05-25}}</ref>
==== Computing for Clean Water ====
# {{Cite journal
|authors=Cao, Wei, Jin Wang and Ming Ma
|title=Carbon nanostructure based mechano-nanofluidics
|url=https://iopscience.iop.org/article/10.1088/1361-6439/aaa782
|journal=Journal of Micromechanics and Microengineering
|date=2018
|doi=10.1088/1361-6439/aaa782
}}
# {{Cite journal
|authors=Ma, Ming, François Grey, Luming Shen, Michael Urbakh, Shuai Wu, Jefferson Zhe Liu, Yilun Liu and Quanshui Zheng
|title=Water transport inside carbon nanotubes mediated by phonon-induced oscillating friction
|url=https://www.nature.com/articles/nnano.2015.134
|journal=Nature Nanotechnology
|date=2015
|doi=10.1038/nnano.2015.134
}}
# {{Cite journal
|authors=Ma, Ming D., Luming Shen, John Sheridan, Jefferson Zhe Liu, Chao Chen and Quanshui Zheng
|title=Friction of water slipping in carbon nanotubes
|url=https://link.aps.org/doi/10.1103/PhysRevE.83.036316
|journal=Physical Review E
|date=2011
|doi=10.1103/PhysRevE.83.036316
}}


Selected publications directly arising from World Community Grid research include:
==== Discovering Dengue Drugs ====
# {{Cite journal
|authors=Viswanathan, Usha, Suzanne M. Tomlinson, John M. Fonner, Stephen A. Mock and Stanley J. Watowich
|title=Identification of a novel inhibitor of dengue virus protease through use of a virtual screening drug discovery Web portal
|url=https://pubmed.ncbi.nlm.nih.gov/25263519/
|journal=Journal of Chemical Information and Modeling
|date=2014
|doi=10.1021/ci500531r
}}
# {{Cite journal
|authors=Tomlinson, S. M., R. D. Malmstrom and S. J. Watowich
|title=New Approaches to Structure-Based Discovery of Dengue Protease Inhibitors
|url=https://www.eurekaselect.com/article/29502
|journal=Infectious Disorders - Drug Targets
|date=2009
|doi=10.2174/1871526510909030327
}}


* Ekins S, Perryman AL, Andrade CH. '''OpenZika: An IBM World Community Grid Project to Accelerate Zika Virus Drug Discovery.''' ''PLOS Neglected Tropical Diseases.'' 2016;10(10):e0005023. DOI: [https://doi.org/10.1371/journal.pntd.0005023 10.1371/journal.pntd.0005023]<ref name="openzika"/>
==== Drug Search for Leishmaniasis ====
# {{Cite journal
|authors=Ochoa, Rodrigo, Stanley J. Watowich, Andrés Flórez, Carol V. Mesa, Sara M. Robledo and Carlos Muskus
|title=Drug search for leishmaniasis: a virtual screening approach by grid computing
|url=https://doi.org/10.1007/s10822-016-9921-4
|journal=Journal of Computer-Aided Molecular Design
|date=2016
|doi=10.1007/s10822-016-9921-4
}}
# {{Cite web
|authors=Flórez, Andrés F., Stanley Watowich, Carlos Muskus, Andrés F. Flórez, Stanley Watowich and Carlos Muskus
|title=Current Advances in Computational Strategies for Drug Discovery in Leishmaniasis
|url=https://www.intechopen.com/state.item.id
|date=2012
}}


* Surpeta B ''et al.'' '''FightAIDS@Home — Phase 2: Discovery of New HIV-1 Capsid Vulnerabilities.''' (Peer-reviewed; referenced in Wikipedia citations 10-13.)<ref name="wcg-wp"/>
==== FightAIDS@Home ====
# {{Cite journal
|authors=Sun, Q., A. Biswas, R. S. K. Vijayan et al.
|title=Structure-based virtual screening workflow to identify antivirals targeting HIV-1 capsid
|url=https://doi.org/10.1007/s10822-022-00446-5
|journal=Journal of Computer-Aided Molecular Design
|date=2022
|doi=10.1007/s10822-022-00446-5
}}
# {{Cite journal
|authors=Goodsell, David S., Michel F. Sanner, Arthur J. Olson and Stefano Forli
|title=The AutoDock suite at 30
|url=https://onlinelibrary.wiley.com/doi/10.1002/pro.3934
|journal=Protein Science
|date=2021
|doi=10.1002/pro.3934
}}
# {{Cite journal
|authors=Craveur, Pierrick, Anna T. Gres, Karen A. Kirby et al
|title=Novel Intersubunit Interaction Critical for HIV-1 Core Assembly Defines a Potentially Targetable Inhibitor Binding Pocket
|url=https://journals.asm.org/doi/10.1128/mBio.02858-18
|journal=mBio
|date=2019
|doi=10.1128/mBio.02858-18
}}
# {{Cite journal
|authors=Xia, Junchao, William Flynn, Emilio Gallicchio, Keith Uplinger, Jonathan D. Armstrong, Stefano Forli, Arthur J. Olson and Ronald M. Levy
|title=Massive-Scale Binding Free Energy Simulations of HIV Integrase Complexes Using Asynchronous Replica Exchange Framework Implemented on the IBM WCG Distributed Network
|url=https://doi.org/10.1021/acs.jcim.8b00817
|journal=Journal of Chemical Information and Modeling
|date=2019
|doi=10.1021/acs.jcim.8b00817
}}
# {{Cite web
|authors=Forli, Stefano and Arthur J. Olson
|title=Computational Challenges of Structure-Based Approaches Applied to HIV
|url=https://link.springer.com/10.1007/82_2015_432
|website=The Future of HIV-1 Therapeutics
|date=2015
}}
# {{Cite journal
|authors=Xia, Junchao, William F. Flynn, Emilio Gallicchio, Bin W. Zhang, Peng He, Zhiqiang Tan and Ronald M. Levy
|title=Large-scale asynchronous and distributed multidimensional replica exchange molecular simulations and efficiency analysis
|url=https://onlinelibrary.wiley.com/doi/abs/10.1002/jcc.23996
|journal=Journal of Computational Chemistry
|date=2015
|doi=10.1002/jcc.23996
}}
# {{Cite journal
|authors=Gallicchio, Emilio, Junchao Xia, William F. Flynn, Baofeng Zhang, Sade Samlalsingh, Ahmet Mentes and Ronald M. Levy
|title=Asynchronous replica exchange software for grid and heterogeneous computing
|url=https://www.sciencedirect.com/science/article/pii/S0010465515002556
|journal=Computer Physics Communications
|date=2015
|doi=10.1016/j.cpc.2015.06.010
}}
# {{Cite journal
|authors=Perryman, Alexander L., Daniel N. Santiago, Stefano Forli, Diogo Santos-Martins and Arthur J. Olson
|title=Virtual screening with AutoDock Vina and the common pharmacophore engine of a low diversity library of fragments and hits against the three allosteric sites of HIV integrase: participation in the SAMPL4 protein–ligand binding challenge
|url=http://link.springer.com/10.1007/s10822-014-9709-3
|journal=Journal of Computer-Aided Molecular Design
|date=2014
|doi=10.1007/s10822-014-9709-3
}}
# {{Cite journal
|authors=Perryman, Alexander L., Qing Zhang, Holly H. Soutter, Robin Rosenfeld, Duncan E. McRee, Arthur J. Olson, John E. Elder and C. David Stout
|title=Fragment-Based Screen against HIV Protease
|url=https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1747-0285.2009.00943.x
|journal=Chemical Biology & Drug Design
|date=2010
|doi=10.1111/j.1747-0285.2009.00943.x
}}
# {{Cite journal
|authors=Perryman, Alex L., Stefano Forli, Garrett M. Morris et al
|title=A Dynamic Model of HIV Integrase Inhibition and Drug Resistance
|url=https://linkinghub.elsevier.com/retrieve/pii/S0022283610000793
|journal=Journal of Molecular Biology
|date=2010
|doi=10.1016/j.jmb.2010.01.033
}}
# {{Cite journal
|authors=Cosconati, Sandro, Stefano Forli, Alex L Perryman, Rodney Harris, David S Goodsell and Arthur J Olson
|title=Virtual Screening with AutoDock: Theory and Practice
|url=http://www.tandfonline.com/doi/full/10.1517/17460441.2010.484460
|journal=Expert Opinion on Drug Discovery
|date=2010
|doi=10.1517/17460441.2010.484460
}}
# {{Cite journal
|authors=Morris, Garrett M., Ruth Huey, William Lindstrom, Michel F. Sanner, Richard K. Belew, David S. Goodsell and Arthur J. Olson
|title=AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility
|url=https://onlinelibrary.wiley.com/doi/10.1002/jcc.21256
|journal=Journal of Computational Chemistry
|date=2009
|doi=10.1002/jcc.21256
}}
# {{Cite journal
|authors=Chang, Max W., William Lindstrom, Arthur J. Olson and Richard K. Belew
|title=Analysis of HIV Wild-Type and Mutant Structures via in Silico Docking against Diverse Ligand Libraries
|url=https://doi.org/10.1021/ci700044s
|journal=Journal of Chemical Information and Modeling
|date=2007
|doi=10.1021/ci700044s
}}


* Hachmann AB ''et al.'' (Clean Energy Project). '''Large-scale computational screening of organic photovoltaic materials'''; database of 2.3+ million characterized organic molecules published 2013.<ref name="wcg-wp"/>
==== GO Fight Against Malaria ====
# {{Cite journal
|authors=Perryman, Alexander L., Weixuan Yu, Xin Wang et al
|title=A Virtual Screen Discovers Novel, Fragment-Sized Inhibitors of Mycobacterium tuberculosis InhA
|url=https://doi.org/10.1021/ci500672v
|journal=Journal of Chemical Information and Modeling
|date=2015
|doi=10.1021/ci500672v
}}
 
==== Genome Comparison ====
# {{Cite web
|authors=Lifschitz, Sérgio, Carlos Juliano M. Viana, Cristian Tristão, Marcos Catanho, Wim M. Degrave, Antonio Basílio de Miranda, Márcia Bezerra and Thomas D. Otto
|title=Design and Implementation of ProteinWorldDB
|url=http://link.springer.com/10.1007/978-3-642-31927-3_13
|website=Advances in Bioinformatics and Computational Biology
|date=2012
}}
# {{Cite journal
|authors=Otto, Thomas Dan, Marcos Catanho, Cristian Tristão et al
|title=ProteinWorldDB: querying radical pairwise alignments among protein sets from complete genomes
|url=https://doi.org/10.1093/bioinformatics/btq011
|journal=Bioinformatics
|date=2010
|doi=10.1093/bioinformatics/btq011
}}
 
==== Help Conquer Cancer ====
# {{Cite journal
|authors=Kotseruba, Yulia, Christian A. Cumbaa and Igor Jurisica
|title=High-throughput protein crystallization on the World Community Grid and the GPU
|url=https://dx.doi.org/10.1088/1742-6596/341/1/012027
|journal=Journal of Physics: Conference Series
|date=2012
|doi=10.1088/1742-6596/341/1/012027
}}
# {{Cite journal
|authors=Cumbaa, Christian A. and Igor Jurisica
|title=Protein crystallization analysis on the World Community Grid
|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857471/
|journal=Journal of Structural and Functional Genomics
|date=2010
|doi=10.1007/s10969-009-9076-9
}}
# {{Cite journal
|authors=Snell, Edward H., Angela M. Lauricella, Stephen A. Potter et al
|title=Establishing a training set through the visual analysis of crystallization trials. Part II: crystal examples
|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631118/
|journal=Acta Crystallographica Section D: Biological Crystallography
|date=2008
|doi=10.1107/S0907444908028059
}}
# {{Cite journal
|authors=Snell, Edward H., Joseph R. Luft, Stephen A. Potter et al
|title=Establishing a training set through the visual analysis of crystallization trials. Part I: ~150 000 images
|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631114/
|journal=Acta Crystallographica Section D: Biological Crystallography
|date=2008
|doi=10.1107/S0907444908028047
}}
 
==== Help Cure Muscular Dystrophy ====
# {{Cite journal
|authors=Dequeker, Chloé, Elodie Laine and Alessandra Carbone
|title=Decrypting protein surfaces by combining evolution, geometry, and molecular docking
|url=https://onlinelibrary.wiley.com/doi/abs/10.1002/prot.25757
|journal=Proteins: Structure, Function, and Bioinformatics
|date=2019
|doi=10.1002/prot.25757
}}
# {{Cite journal
|authors=Lagarde, Nathalie, Alessandra Carbone and Sophie Sacquin-Mora
|title=Hidden partners: Using cross-docking calculations to predict binding sites for proteins with multiple interactions
|url=https://onlinelibrary.wiley.com/doi/abs/10.1002/prot.25506
|journal=Proteins: Structure, Function, and Bioinformatics
|date=2018
|doi=10.1002/prot.25506
}}
# {{Cite journal
|authors=Laine, Elodie and Alessandra Carbone
|title=Protein social behavior makes a stronger signal for partner identification than surface geometry
|url=https://onlinelibrary.wiley.com/doi/abs/10.1002/prot.25206
|journal=Proteins: Structure, Function, and Bioinformatics
|date=2017
|doi=10.1002/prot.25206
}}
# {{Cite journal
|authors=Vamparys, Lydie, Benoist Laurent, Alessandra Carbone and Sophie Sacquin-Mora
|title=Great interactions: How binding incorrect partners can teach us about protein recognition and function
|url=https://onlinelibrary.wiley.com/doi/abs/10.1002/prot.25086
|journal=Proteins: Structure, Function, and Bioinformatics
|date=2016
|doi=10.1002/prot.25086
}}
# {{Cite journal
|authors=Lopes, Anne, Sophie Sacquin-Mora, Viktoriya Dimitrova, Elodie Laine, Yann Ponty and Alessandra Carbone
|title=Protein-Protein Interactions in a Crowded Environment: An Analysis via Cross-Docking Simulations and Evolutionary Information
|url=https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1003369
|journal=PLOS Computational Biology
|date=2013
|doi=10.1371/journal.pcbi.1003369
}}
# {{Cite journal
|authors=Bertis, Viktors, Raphaël Bolze, Frédéric Desprez and Kevin Reed
|title=From Dedicated Grid to Volunteer Grid: Large Scale Execution of a Bioinformatics Application
|url=https://doi.org/10.1007/s10723-009-9130-7
|journal=Journal of Grid Computing
|date=2009
|doi=10.1007/s10723-009-9130-7
}}
# {{Cite journal
|authors=Engelen, Stefan, Ladislas A. Trojan, Sophie Sacquin-Mora, Richard Lavery and Alessandra Carbone
|title=Joint Evolutionary Trees: A Large-Scale Method To Predict Protein Interfaces Based on Sequence Sampling
|url=https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1000267
|journal=PLOS Computational Biology
|date=2009
|doi=10.1371/journal.pcbi.1000267
}}
# {{Cite journal
|authors=Sacquin-Mora, Sophie, Alessandra Carbone and Richard Lavery
|title=Identification of Protein Interaction Partners and Protein–Protein Interaction Sites
|url=https://www.sciencedirect.com/science/article/pii/S002228360800973X
|journal=Journal of Molecular Biology
|date=2008
|doi=10.1016/j.jmb.2008.08.002
}}
 
==== Help Defeat Cancer ====
# {{Cite journal
|authors=Foran, David J, Lin Yang, Wenjin Chen et al
|title=ImageMiner: a software system for comparative analysis of tissue microarrays using content-based image retrieval, high-performance computing, and grid technology
|url=https://academic.oup.com/jamia/article-lookup/doi/10.1136/amiajnl-2011-000170
|journal=Journal of the American Medical Informatics Association
|date=2011
|doi=10.1136/amiajnl-2011-000170
}}
# {{Cite web
|authors=Wang, Fusheng
|title=Grid-Enabled, High-performance Microscopy Image Analysis
|url=https://www.academia.edu/en/50457695/Grid_Enabled_High_performance_Microscopy_Image_Analysis
|date=2010
}}
# {{Cite journal
|authors=Lin Yang, Wenjin Chen, P. Meer, G. Salaru, L.A. Goodell, V. Berstis and D.J. Foran
|title=Virtual Microscopy and Grid-Enabled Decision Support for Large-Scale Analysis of Imaged Pathology Specimens
|url=http://ieeexplore.ieee.org/document/4814676/
|journal=IEEE Transactions on Information Technology in Biomedicine
|date=2009
|doi=10.1109/TITB.2009.2020159
}}
# {{Cite journal
|authors=Lin Yang, O. Tuzel, Wenjin Chen, P. Meer, G. Salaru, L.A. Goodell and D.J. Foran
|title=PathMiner: A Web-Based Tool for Computer-Assisted Diagnostics in Pathology
|url=http://ieeexplore.ieee.org/document/4757270/
|journal=IEEE Transactions on Information Technology in Biomedicine
|date=2009
|doi=10.1109/TITB.2008.2008801
}}
# {{Cite journal
|authors=DiPaola, Robert S., Dmitri Dvorzhinski, Anu Thalasila et al
|title=Therapeutic starvation and autophagy in prostate cancer: A new paradigm for targeting metabolism in cancer therapy
|url=https://onlinelibrary.wiley.com/doi/abs/10.1002/pros.20837
|journal=The Prostate
|date=2008
|doi=10.1002/pros.20837
}}
 
==== Help Fight Childhood Cancer ====
# {{Cite journal
|authors=Fukuda, Mayu, Atsushi Takatori, Yohko Nakamura, Akiko Suganami, Tyuji Hoshino, Yutaka Tamura and Akira Nakagawara
|title=Effects of novel small compounds targeting TrkB on neuronal cell survival and depression-like behavior
|url=https://www.sciencedirect.com/science/article/pii/S0197018616300869
|journal=Neurochemistry International
|date=2016
|doi=10.1016/j.neuint.2016.04.017
}}
# {{Cite journal
|authors=Nakamura, Yohko, Akiko Suganami, Mayu Fukuda et al
|title=Identification of novel candidate compounds targeting TrkB to induce apoptosis in neuroblastoma
|url=https://onlinelibrary.wiley.com/doi/abs/10.1002/cam4.175
|journal=Cancer Medicine
|date=2014
|doi=10.1002/cam4.175
}}
 
==== Help Stop TB ====
# {{Cite journal
|authors=Groenewald, Wilma, Ricardo A. Parra-Cruz, Christof M. Jäger and Anna K. Croft
|title=Revealing solvent-dependent folding behavior of mycolic acids from Mycobacterium tuberculosis by advanced simulation analysis
|url=http://link.springer.com/10.1007/s00894-019-3943-5
|journal=Journal of Molecular Modeling
|date=2019
|doi=10.1007/s00894-019-3943-5
}}
 
==== Human Proteome Folding ====
# {{Cite journal
|authors=Baltz, Alexander G., Mathias Munschauer, Björn Schwanhäusser et al
|title=The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts
|url=https://linkinghub.elsevier.com/retrieve/pii/S1097276512004376
|journal=Molecular Cell
|date=2012
|doi=10.1016/j.molcel.2012.05.021
}}
# {{Cite journal
|authors=Pentony, M. M., P. Winters, D. Penfold-Brown, K. Drew, A. Narechania, R. DeSalle, R. Bonneau and M. D. Purugganan
|title=The Plant Proteome Folding Project: Structure and Positive Selection in Plant Protein Families
|url=https://doi.org/10.1093/gbe/evs015
|journal=Genome Biology and Evolution
|date=2012
|doi=10.1093/gbe/evs015
}}
# {{Cite journal
|authors=Drew, Kevin, Patrick Winters, Glenn L. Butterfoss et al
|title=The Proteome Folding Project: Proteome-scale prediction of structure and function
|url=http://genome.cshlp.org/lookup/doi/10.1101/gr.121475.111
|journal=Genome Research
|date=2011
|doi=10.1101/gr.121475.111
}}
# {{Cite journal
|authors=Boxem, Mike, Zoltan Maliga, Niels Klitgord et al
|title=A Protein Domain-Based Interactome Network for C. elegans Early Embryogenesis
|url=https://www.sciencedirect.com/science/article/pii/S0092867408008866
|journal=Cell
|date=2008
|doi=10.1016/j.cell.2008.07.009
}}
# {{Cite journal
|authors=Bonneau, Richard, Marc T. Facciotti, David J. Reiss et al
|title=A Predictive Model for Transcriptional Control of Physiology in a Free Living Cell
|url=https://www.cell.com/cell/abstract/S0092-8674(07)01416-X
|journal=Cell
|date=2007
|doi=10.1016/j.cell.2007.10.053
}}
# {{Cite journal
|authors=Malmström, Lars, Michael Riffle, Charlie E. M. Strauss, Dylan Chivian, Trisha N. Davis, Richard Bonneau and David Baker
|title=Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology
|url=https://pubmed.ncbi.nlm.nih.gov/17373854/
|journal=PLoS biology
|date=2007
|doi=10.1371/journal.pbio.0050076
}}
# {{Cite journal
|authors=Andersen-Nissen, Erica, Kelly D. Smith, Richard Bonneau, Roland K. Strong and Alan Aderem
|title=A conserved surface on Toll-like receptor 5 recognizes bacterial flagellin
|url=https://doi.org/10.1084/jem.20061400
|journal=Journal of Experimental Medicine
|date=2007
|doi=10.1084/jem.20061400
}}
# {{Cite journal
|authors=Avila-Campillo, Iliana, Kevin Drew, John Lin, David J. Reiss and Richard Bonneau
|title=BioNetBuilder: automatic integration of biological networks
|url=https://doi.org/10.1093/bioinformatics/btl604
|journal=Bioinformatics
|date=2007
|doi=10.1093/bioinformatics/btl604
}}
# {{Cite web
|authors=Malmström, Lars
|title=Genome-wide structural and functional protein characterization by ab initio protein structure prediction
|url=http://lars.malmstroem.net/lars.malmstroem.thesis.no_articles.pdf
|website=Report / Department of Electrical Measurements. Lund Institute of Technology
|date=2005
}}
 
==== Mapping Cancer Markers ====
# {{Cite journal
|authors=Kotlyar, M., C. Pastrello, M. Abovsky, A. Mizeranschi, A. Keating, L. C. Cameron, V. Chandran and I. Jurisica
|title=IID 2025: Physical protein interaction data with detection types, co-purified protein sets, molecular docking, and immune cell networks
|url=https://doi.org/10.1093/nar/gkaf1004
|journal=Nucleic Acids Research
|date=2026
}}
# {{Cite journal
|authors=Kotlyar, M., C. Pastrello, Z. Ahmed, J. Chee, Z. Varyova and I. Jurisica
|title=IID 2021: towards context-specific protein interaction analyses by increased coverage, enhanced annotation and enrichment analysis
|url=https://doi.org/10.1093/nar/gkab1034
|journal=Nucleic Acids Research
|date=2022
|doi=10.1093/nar/gkab1034
}}
# {{Cite journal
|authors=Kotlyar, M., C. Pastrello, Z. Malik and I. Jurisica
|title=IID 2018 update: context-specific physical protein-protein interactions in human, model organisms and domesticated species
|url=https://doi.org/10.1093/nar/gky1037
|journal=Nucleic Acids Research
|date=2019
}}
# {{Cite journal
|authors=Kotlyar, M., C. Pastrello, N. Sheahan and I. Jurisica
|title=Integrated Interactions Database: tissue-specific view of the human and model organism interactomes
|url=https://doi.org/10.1093/nar/gkv1115
|journal=Nucleic Acids Research
|date=2016
}}
# {{Cite web
|authors=Pastrello, C., M. Kotlyar and I. Jurisica
|title=Informed Use of Protein-Protein Interaction Data: A Focus on the Integrated Interactions Database (IID)
|url=https://doi.org/10.1007/978-1-4939-9873-9_10
|website=Methods in Molecular Biology
|date=2020
}}
# {{Cite journal
|authors=Wong, S. W. H., C. Pastrello, M. Kotlyar, C. Faloutsos and I. Jurisica
|title=USNAP: fast unique dense region detection and its application to lung cancer
|url=https://doi.org/10.1093/bioinformatics/btad477
|journal=Bioinformatics
|date=2023
|doi=10.1093/bioinformatics/btad477
}}
# {{Cite journal
|authors=Wong, S. W. H., N. Cercone and I. Jurisica
|title=Comparative network analysis via differential graphlet communities
|url=https://doi.org/10.1002/pmic.201400233
|journal=Proteomics
|date=2015
|doi=10.1002/pmic.201400233
}}
# {{Cite journal
|authors=Hauschild, Anne-Christin, Chiara Pastrello, Andrea E.M. Rossos and Igor Jurisica
|title=Visualization of Biomedical Networks
|url=https://linkinghub.elsevier.com/retrieve/pii/B9780128096338204305
|journal=Encyclopedia of Bioinformatics and Computational Biology
|date=2019
}}
# {{Cite journal
|authors=Paulitti, Alice, Eva Andreuzzi, Dario Bizzotto et al.
|title=The ablation of the matricellular protein EMILIN2 causes defective vascularization due to impaired EGFR-dependent IL-8 production affecting tumor growth
|url=https://www.nature.com/articles/s41388-017-0107-x
|journal=Oncogene
|date=2018
|doi=10.1038/s41388-017-0107-x
}}
# {{Cite journal
|authors=Wong, Serene W.H., Chiara Pastrello, Max Kotlyar, Christos Faloutsos and Igor Jurisica
|title=SDREGION: Fast Spotting of Changing Communities in Biological Networks
|url=https://dl.acm.org/doi/10.1145/3219819.3219854
|journal=KDD '18: The 24th ACM SIGKDD International Conference on Knowledge Discovery and Data Mining
|date=2018
|doi=10.1145/3219819.3219854
}}
# {{Cite web
|authors=Anne-Christin Hauschild, Christian A Cumbaa, Mike Tsay and Igor Jurisica
|title=Network Motif Families for Lung Cancer Diagnostics: A World Community Grid Approach
|url=http://rgdoi.net/10.13140/RG.2.2.34687.51363
|date=2017
}}
# {{Cite journal
|authors=Fortney, Kristen, Joshua Griesman, Max Kotlyar, Chiara Pastrello, Marc Angeli, Ming Sound-Tsao and Igor Jurisica
|title=Prioritizing Therapeutics for Lung Cancer: An Integrative Meta-analysis of Cancer Gene Signatures and Chemogenomic Data
|url=https://dx.plos.org/10.1371/journal.pcbi.1004068
|journal=PLOS Computational Biology
|date=2015
|doi=10.1371/journal.pcbi.1004068
}}
# {{Cite journal
|authors=Kotlyar, Max, Chiara Pastrello, Flavia Pivetta et al.
|title=In silico prediction of physical protein interactions and characterization of interactome orphans
|url=https://www.nature.com/articles/nmeth.3178
|journal=Nature Methods
|date=2015
|doi=10.1038/nmeth.3178
}}
 
==== Microbiome Immunity Project ====
# {{Cite journal
|authors=Koehler Leman, Julia, Pawel Szczerbiak, P. Douglas Renfrew et al.
|title=Sequence-structure-function relationships in the microbial protein universe
|url=https://www.nature.com/articles/s41467-023-37896-w
|journal=Nature Communications
|date=2023
|doi=10.1038/s41467-023-37896-w
}}
 
==== Nutritious Rice for the World ====
# {{Cite journal
|authors=Hung, Ling-Hong and Ram Samudrala
|title=Rice protein models from the Nutritious Rice for the World Project
|url=https://www.biorxiv.org/content/10.1101/091975v1
|journal=biorxiv
|date=2016
|doi=10.1101/091975
}}
# {{Cite journal
|authors=Hung, Ling-Hong and Ram Samudrala
|title=fast_protein_cluster: parallel and optimized clustering of large-scale protein modeling data
|url=https://doi.org/10.1093/bioinformatics/btu098
|journal=Bioinformatics
|date=2014
|doi=10.1093/bioinformatics/btu098
}}
# {{Cite journal
|authors=Hung, Ling-Hong and Ram Samudrala
|title=Accelerated protein structure comparison using TM-score-GPU
|url=https://academic.oup.com/bioinformatics/article-lookup/doi/10.1093/bioinformatics/bts345
|journal=Bioinformatics
|date=2012
|doi=10.1093/bioinformatics/bts345
}}
# {{Cite journal
|authors=Hung, Ling-Hong, Michal Guerquin and Ram Samudrala
|title=GPU-Q-J, a fast method for calculating root mean square deviation (RMSD) after optimal superposition
|url=https://bmcresnotes.biomedcentral.com/articles/10.1186/1756-0500-4-97
|journal=BMC Research Notes
|date=2011
|doi=10.1186/1756-0500-4-97
}}
 
==== OpenZika ====
# {{Cite journal
|authors=Mottin, Melina, Bruna Katiele de Paula Sousa, Nathalya Cristina de Moraes Roso Mesquita et al.
|title=Discovery of New Zika Protease and Polymerase Inhibitors through the Open Science Collaboration Project OpenZika
|url=https://pubs.acs.org/doi/10.1021/acs.jcim.2c00596
|journal=Journal of Chemical Information and Modeling
|date=2022
|doi=10.1021/acs.jcim.2c00596
}}
# {{Cite journal
|authors=Silva, Suely, Jacqueline Farinha Shimizu, Débora Moraes de Oliveira et al.
|title=A diarylamine derived from anthranilic acid inhibits ZIKV replication
|url=https://www.nature.com/articles/s41598-019-54169-z
|journal=Scientific Reports
|date=2019
|doi=10.1038/s41598-019-54169-z
}}
# {{Cite journal
|authors=Hernandez, Helen W., Melinda Soeung, Kimberley M. Zorn et al.
|title=High Throughput and Computational Repurposing for Neglected Diseases
|url=http://link.springer.com/10.1007/s11095-018-2558-3
|journal=Pharmaceutical Research
|date=2019
|doi=10.1007/s11095-018-2558-3
}}
# {{Cite journal
|authors=Mottin, Melina, Joyce Villa Verde Bastos Borba, Cleber Camilo Melo-Filho et al.
|title=Computational drug discovery for the Zika virus
|url=http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000700401&lng=en&tlng=en
|journal=Brazilian Journal of Pharmaceutical Sciences
|date=2018
|doi=10.1590/s2175-97902018000001002
}}
# {{Cite journal
|authors=Mottin, Melina, Joyce V.V.B. Borba, Rodolpho C. Braga et al.
|title=The A–Z of Zika drug discovery
|url=https://linkinghub.elsevier.com/retrieve/pii/S1359644618300412
|journal=Drug Discovery Today
|date=2018
|doi=10.1016/j.drudis.2018.06.014
}}
# {{Cite journal
|authors=Mottin, Melina, Rodolpho C. Braga, Roosevelt A. da Silva, Joao H. Martins da Silva, Alexander L. Perryman, Sean Ekins and Carolina Horta Andrade
|title=Molecular dynamics simulations of Zika virus NS3 helicase: Insights into RNA binding site activity
|url=https://linkinghub.elsevier.com/retrieve/pii/S0006291X1730534X
|journal=Biochemical and Biophysical Research Communications
|date=2017
|doi=10.1016/j.bbrc.2017.03.070
}}
# {{Cite journal
|authors=Ekins, Sean, Alexander L. Perryman and Carolina Horta Andrade
|title=OpenZika: An IBM World Community Grid Project to Accelerate Zika Virus Drug Discovery
|url=https://dx.plos.org/10.1371/journal.pntd.0005023
|journal=PLOS Neglected Tropical Diseases
|date=2016
|doi=10.1371/journal.pntd.0005023
}}
# {{Cite journal
|authors=Ekins, Sean, John Liebler, Bruno J. Neves, Warren G. Lewis, Megan Coffee, Rachelle Bienstock, Christopher Southan and Carolina H. Andrade
|title=Illustrating and homology modeling the proteins of the Zika virus
|url=https://f1000research.com/articles/5-275/v2
|journal=F1000Research
|date=2016
|doi=10.12688/f1000research.8213.2
}}
 
==== The Clean Energy Project ====
# {{Cite journal
|authors=Lopez, Steven A., Benjamin Sanchez-Lengeling, Julio De Goes Soares and Alán Aspuru-Guzik
|title=Design Principles and Top Non-Fullerene Acceptor Candidates for Organic Photovoltaics
|url=https://linkinghub.elsevier.com/retrieve/pii/S2542435117301307
|journal=Joule
|date=2017
|doi=10.1016/j.joule.2017.10.006
}}
# {{Cite journal
|authors=Pyzer-Knapp, Edward O., Changwon Suh, Rafael Gómez-Bombarelli, Jorge Aguilera-Iparraguirre and Alán Aspuru-Guzik
|title=What Is High-Throughput Virtual Screening? A Perspective from Organic Materials Discovery
|url=https://doi.org/10.1146/annurev-matsci-070214-020823
|journal=Annual Review of Materials Research
|date=2015
|doi=10.1146/annurev-matsci-070214-020823
}}
# {{Cite journal
|authors=Pyzer-Knapp, Edward O., Kewei Li and Alan Aspuru-Guzik
|title=Learning from the Harvard Clean Energy Project: The Use of Neural Networks to Accelerate Materials Discovery
|url=https://onlinelibrary.wiley.com/doi/abs/10.1002/adfm.201501919
|journal=Advanced Functional Materials
|date=2015
|doi=10.1002/adfm.201501919
}}
# {{Cite journal
|authors=Hachmann, Johannes, Roberto Olivares-Amaya, Adrian Jinich et al.
|title=Lead candidates for high-performance organic photovoltaics from high-throughput quantum chemistry – the Harvard Clean Energy Project
|url=http://xlink.rsc.org/?DOI=C3EE42756K
|journal=Energy Environ. Sci.
|date=2014
|doi=10.1039/C3EE42756K
}}
# {{Cite journal
|authors=Olivares-Amaya, Roberto, Carlos Amador-Bedolla, Johannes Hachmann, Sule Atahan-Evrenk, Roel S. Sánchez-Carrera, Leslie Vogt and Alán Aspuru-Guzik
|title=Accelerated computational discovery of high-performance materials for organic photovoltaics by means of cheminformatics
|url=http://xlink.rsc.org/?DOI=c1ee02056k
|journal=Energy & Environmental Science
|date=2011
|doi=10.1039/c1ee02056k
}}
# {{Cite journal
|authors=Hachmann, Johannes, Roberto Olivares-Amaya, Sule Atahan-Evrenk et al.
|title=The Harvard Clean Energy Project: Large-Scale Computational Screening and Design of Organic Photovoltaics on the World Community Grid
|url=https://doi.org/10.1021/jz200866s
|journal=The Journal of Physical Chemistry Letters
|date=2011
|doi=10.1021/jz200866s
}}
# {{Cite journal
|authors=Sokolov, Anatoliy N., Sule Atahan-Evrenk, Rajib Mondal et al.
|title=From computational discovery to experimental characterization of a high hole mobility organic crystal
|url=https://www.nature.com/articles/ncomms1451
|journal=Nature Communications
|date=2011
|doi=10.1038/ncomms1451
}}
 
=== Other project-related publications ===
<!-- The papers below are additional Jurisica Lab / Mapping Cancer Markers output found on
https://www.cs.toronto.edu/~juris/jlab/wcg.html that could not be confirmed as using WCG/BOINC-computed
data for this specific paper (general cancer genomics/clinical studies, database papers like pathDIP/mirDIP/MatrixDB,
and review/book chapters). Review before publishing -- author/title splits were done heuristically and dates/DOIs
were not individually re-verified against the original publisher pages. -->
 
==== Mapping Cancer Markers (general lab output) ====
 
=== Other project-related publications ===
<!-- Add publications about WCG subprojects that did not themselves use BOINC-computed data here -->
{{Reflist}}


For the complete and current list of World Community Grid-related papers, see: [https://boinc.berkeley.edu/pubs.php#World BOINC Publications — World Community Grid].


== See Also ==
== See Also ==

Revision as of 19:19, 6 July 2026



World Community Grid
Project
StatusActive
CategoryBiomedical / Humanitarian science
ComputeCPU
RequiresNone
Development
DeveloperUnited Devices (2004); IBM (2004–2022); Krembil Research Institute / UHN (2022–present)
AuthorIBM Corporate Social Responsibility
SponsorUniversity Health Network
MaintainerDr. Igor Jurisica, Krembil Research Institute
Initial releaseNovember 16, 2004  (22 years ago)
Software
Operating systemWindows, Linux, macOS, Android, Raspberry Pi OS
BOINC statistics
Stats as ofJanuary 1, 2023  (3 years ago)
Performance402 TFLOPS
Active users23,248
Total users79,354
Active hosts57,672
Total hosts5,517,865
Metadata
Websitehttps://www.worldcommunitygrid.org/

World Community Grid uses BOINC to accelerate science by creating a supercomputer empowered by a global community of volunteers.

Open Pandemics BOINC Screensaver
Open Pandemics - COVID-19 BOINC Screensaver

World Community Grid (WCG) is a volunteer computing platform dedicated to humanitarian and biomedical scientific research. It harnesses the idle processing power of everyday devices (personal computers, laptops, Android smartphones, and Raspberry Pi systems) to perform large-scale scientific calculations that would otherwise require decades of supercomputing time. Since its founding in 2004, the project has expanded to cover diseases including HIV/AIDS, cancer, tuberculosis, dengue fever, Ebola, Zika virus, and COVID-19, as well as research into clean energy, water purification, food security, and climate science.[1]

Why World Community Grid?

World Community Grid began on November 16, 2004, as a philanthropic initiative of IBM Corporate Social Responsibility, the corporate social responsibility and philanthropy division of IBM.[2] The project was inspired by a successful predecessor: in 2003, IBM and other partners sponsored the United Devices Smallpox Research Grid Project, which used a distributed computing grid to screen 35 million potential drug molecules against several smallpox proteins. In the first 72 hours alone, 100,000 results were returned, and by the project's end, 44 strong treatment candidates had been identified.[3] Encouraged by those results, IBM launched World Community Grid with the goal of creating a permanent technical environment where humanitarian research of this kind could be run continuously.

Through Corporate Social Responsibility, IBM donated its technology and talent to address some of the world's most pressing social and environmental issues. The platform was initially Windows-only and used the proprietary Grid MP client software from United Devices.[4] Demand for broader platform support led to the addition of the open-source BOINC (Berkeley Open Infrastructure for Network Computing) framework in November 2005, bringing Mac OS X and Linux support to the project.[4] By 2007, the Grid MP client had been fully retired and the project consolidated entirely on BOINC.[4]

In September 2021, IBM announced that it had transferred ownership of World Community Grid to the Krembil Research Institute, part of the University Health Network (UHN) in Toronto, Ontario, Canada.[5] Operational management formally transferred to Krembil in February 2022.

Goal

The overarching goal of World Community Grid is to help scientists identify the most important results to study in the laboratory, bringing them one step closer to discoveries that save lives and address global problems. Rather than replacing lab research, WCG acts as a filter: by computationally screening millions — sometimes billions — of candidate molecules or parameter sets, researchers can focus their scarce lab resources on only the most promising leads.

"WCG continues to support open-source and open-data research and helps reduce computational time to allow scientists to address the world's most pressing questions at no cost to the researchers."[5]

All data generated by World Community Grid volunteers must be released into the public domain and made freely available to the scientific community — a foundational requirement for any project accepted onto the platform.[1]

How It Works

World Community Grid runs on top of BOINC, an open-source middleware system developed at the University of California, Berkeley, originally under a National Science Foundation grant.[6] After downloading the WCG client (a pre-configured BOINC installer) from the official website, the software runs quietly in the background. It monitors available system resources and, when the device is idle, downloads a work unit from the WCG servers, performs the required calculations, and sends the results back.

To ensure accuracy, the servers distribute multiple copies of each work unit to different volunteers. When results are returned, they are validated against each other, and statistical outliers are discarded before final data is accepted.[7]

Credits and Points

Volunteer contributions are tracked using the BOINC Credit System. Upon completing a work unit, the BOINC client reports a point value based on software benchmarks (measured in cobblestones, where 1cobblestone=1200GigaFLOP-day). The WCG servers compare claims from each machine that processed the same work unit, discard outliers, and award the averaged value to each contributor.[7] Points allow users to track their personal contribution and compete on leaderboards.

Teams and Partners

Users may join teams created by organizations or individuals, fostering community identity and friendly competition. As of April 2021, World Community Grid had 452 recognized partner organizations promoting the grid within their communities.[7]

CPU Throttling

The BOINC client is designed not to slow down the host computer. World Community Grid sets conservative defaults: the CPU throttle is 60% by default, meaning the client runs at full load for roughly 3 seconds, then pauses for 2 seconds, cycling continuously. This pattern avoids sustained heat buildup. Windows users can additionally install TThrottle, a third-party add-on that reads CPU and GPU temperatures in real time and adjusts computation accordingly.[7]

Methods

Screensaver HUMAN PROTEOME FOLDING Phase2. World Community Grid solving the Human Proteome Folding Project.

Dr. Igor Jurisica's research drives World Community Grid's current scientific direction. Dr. Jurisica is a Senior Scientist at the Krembil Research Institute and a Professor at the University of Toronto, with appointments at Toronto Western Hospital. His work focuses on integrative computational biology — combining large-scale data analysis, machine learning, and network biology to understand complex diseases.

Research within Krembil is focused on the development of diagnostics, treatments and management strategies across three programmatic areas:

  1. Chronic neurological and neurosurgical disorders — including Parkinson's disease, stroke, epilepsy, spinal cord injuries, dementia, concussion, pain, and depression.
  2. Ophthalmologic disorders — including glaucoma, macular degeneration, and retinopathy.
  3. Musculoskeletal system disorders — including osteoarthritis, rheumatoid arthritis, systemic lupus erythematosus, and ankylosing spondylitis.

The primary computational technique used across WCG's biomedical projects is molecular docking, in which candidate drug molecules are algorithmically fitted to target protein structures to predict binding affinity. A typical project may dock tens of millions of compounds against one or more proteins — a task that would require tens of thousands of years of computing time on a single machine, but can be completed in months across the volunteer grid.[8]

Project Team / Sponsors

World Community Grid is currently managed by Dr. Igor Jurisica and his team at the Krembil Research Institute, part of the University Health Network (UHN) in Toronto, Ontario, Canada.[5]

UHN has Canada's largest hospital-based research program, comprising four major teaching hospitals: Toronto Western Hospital, Toronto General Hospital, Princess Margaret Cancer Centre, and Toronto Rehabilitation Institute, as well as The Michener Institute of Education.[9]

Previously, the project was funded and operated by IBM from its launch in November 2004 through February 2022. IBM provided all server infrastructure, administrative overhead, and technical support during that nearly two-decade period. The project is grateful for IBM's extensive financial and operational support.[5]

Research Overview

World Community Grid operates as an umbrella platform hosting multiple research projects simultaneously. Users are enrolled in all active projects by default but may opt out of any they choose.[7] Over the life of the project, WCG volunteers have collectively donated the equivalent of more than 2 million years of computing time and completed more than 6 billion work units.[7]

Active Research

  1. OpenPandemics - COVID-19 — Launched to enable a rapid-response platform for global disease outbreaks, the project uses molecular docking to screen drug candidates against SARS-CoV-2 proteins in partnership with scientists at Scripps Research. The goal is to identify compounds that could block viral replication, potentially forming the basis of antiviral drugs for COVID-19 and future pandemic pathogens.
  1. Mapping Cancer Markers — One of WCG's longest-running and most ambitious projects, this research aims to identify robust molecular biomarkers associated with various cancer types. By decoding cancer-rewired biological networks, researchers hope to enable earlier detection and more personalized treatment strategies.

Intermittent Research

  1. Africa Rainfall Project — Uses regional climate modelling to improve weather forecasts and agricultural planning across sub-Saharan Africa, where rain-fed agriculture supports the food supply for hundreds of millions of people.
  1. Smash Childhood Cancer — An expansion of earlier WCG work on neuroblastoma, this project searches for the best drug candidates targeting key molecular proteins across a broader range of childhood cancers.
  1. Help Stop TB — Focuses on finding new drug leads for tuberculosis (TB), which remains one of the world's leading infectious disease killers. The project performs virtual screening of millions of compounds against TB target proteins.

Completed Research (28)

Over the course of the project's history, 28 research projects have been completed.[10] These include:

Project Focus Area Notable Outcome
Human Proteome Folding (Phase 1 & 2) Protein structure prediction Produced a database of ~120,000 protein domain structures; computation that would have taken 100 years conventionally was done in one year.[11]
FightAIDS@Home (Phase 1 & 2) HIV/AIDS drug discovery Discovered two compounds representing a potentially new class of AIDS-fighting drugs; identified new vulnerabilities on the HIV-1 capsid protein as a possible new drug target.[7]
Help Fight Childhood Cancer Neuroblastoma Screened over 3 million drug candidates; identified 7 compounds that destroy neuroblastoma cells without apparent side effects.[12]
The Clean Energy Project (Phase 1 & 2) Solar cell materials Published a database of over 2.3 million organic molecules; identified 35,000 compounds with potential to double the efficiency of carbon-based organic solar cells.[7]
OpenZika Zika virus drug discovery Identified compound FAM 3, which inhibits the NS3 Helicase protein of the Zika virus, reducing viral replication by up to 86%.[13]
GO Fight Against Malaria Malaria and drug-resistant TB First WCG project to complete a billion docking calculations; discovered several molecules effective against malaria and drug-resistant tuberculosis including TDR-TB.[7]
Discovering Dengue Drugs Together (Phase 1 & 2) Dengue fever and Flaviviridae Identified several new dengue protease inhibitors, many of which also inhibit the West Nile virus protease.[7]
Help Conquer Cancer Protein crystallography for cancer Analysis that would have taken 162 years on conventional computers was completed in under 2 years.[14]
Nutritious Rice for the World Food security / crop genetics Predicted protein structures for major rice strains to help breed higher-yield, more disease-resistant varieties.[10]
Computing for Clean Water Nanotechnology / water filtration Studied molecular-scale water flow through novel filter materials to guide development of low-cost water filters.[10]
Drug Search for Leishmaniasis Neglected tropical disease Tested top 10 compounds in vivo; one compound induced near-complete curing of lesions in hamsters.[7]
AfricanClimate@Home Climate modelling Developed more accurate regional climate models for Africa.[10]
Outsmart Ebola Together Ebola drug discovery Screened millions of compounds against Ebola viral proteins to identify drug leads.[10]
Microbiome Immunity Project Human microbiome Comprehensive study of the role of gut bacteria in human disease.[10]
Uncovering Genome Mysteries Genomics Examined close to 200 million genes from diverse organisms.[10]
Help Cure Muscular Dystrophy (Phase 1 & 2) Neuromuscular diseases Investigated protein interactions for more than 2,200 structurally known proteins linked to muscular dystrophy and related diseases.[10]
Influenza Antiviral Drug Search Influenza Searched for drugs effective against drug-resistant and novel influenza strains.[10]
Smash Childhood Cancer Pediatric cancers (broader) Expanded neuroblastoma drug discovery to additional childhood cancer types.[10]
Help Defeat Cancer Tissue microarray analysis Examined cancer tissue microarrays to improve precision medicine diagnosis and treatment.[10]
Genome Comparison Comparative genomics Compared genomic information to improve biological data quality and host-pathogen understanding; led by Fiocruz (Oswaldo Cruz Institute), Brazil.[10]
Say No to Schistosoma Schistosomiasis Identified potential drug candidates for schistosomiasis, a neglected tropical disease affecting hundreds of millions.[10]
Computing for Sustainable Water Watershed ecology Modelled nutrient flows and ecological responses across 64,000 km2 of the Chesapeake Bay watershed.[10]

Publications

Papers using BOINC-computed data

Computing for Clean Water

  1. (2018).Carbon nanostructure based mechano-nanofluidics. Journal of Micromechanics and Microengineering. DOI: 10.1088/1361-6439/aaa782.
  2. (2015).Water transport inside carbon nanotubes mediated by phonon-induced oscillating friction. Nature Nanotechnology. DOI: 10.1038/nnano.2015.134.
  3. (2011).Friction of water slipping in carbon nanotubes. Physical Review E. DOI: 10.1103/PhysRevE.83.036316.

Discovering Dengue Drugs

  1. (2014).Identification of a novel inhibitor of dengue virus protease through use of a virtual screening drug discovery Web portal. Journal of Chemical Information and Modeling. DOI: 10.1021/ci500531r.
  2. (2009).New Approaches to Structure-Based Discovery of Dengue Protease Inhibitors. Infectious Disorders - Drug Targets. DOI: 10.2174/1871526510909030327.

Drug Search for Leishmaniasis

  1. (2016).Drug search for leishmaniasis: a virtual screening approach by grid computing. Journal of Computer-Aided Molecular Design. DOI: 10.1007/s10822-016-9921-4.
  2. (2012).Current Advances in Computational Strategies for Drug Discovery in Leishmaniasis.

FightAIDS@Home

  1. (2022).Structure-based virtual screening workflow to identify antivirals targeting HIV-1 capsid. Journal of Computer-Aided Molecular Design. DOI: 10.1007/s10822-022-00446-5.
  2. (2021).The AutoDock suite at 30. Protein Science. DOI: 10.1002/pro.3934.
  3. (2019).Novel Intersubunit Interaction Critical for HIV-1 Core Assembly Defines a Potentially Targetable Inhibitor Binding Pocket. mBio. DOI: 10.1128/mBio.02858-18.
  4. (2019).Massive-Scale Binding Free Energy Simulations of HIV Integrase Complexes Using Asynchronous Replica Exchange Framework Implemented on the IBM WCG Distributed Network. Journal of Chemical Information and Modeling. DOI: 10.1021/acs.jcim.8b00817.
  5. (2015).Computational Challenges of Structure-Based Approaches Applied to HIV. The Future of HIV-1 Therapeutics.
  6. (2015).Large-scale asynchronous and distributed multidimensional replica exchange molecular simulations and efficiency analysis. Journal of Computational Chemistry. DOI: 10.1002/jcc.23996.
  7. (2015).Asynchronous replica exchange software for grid and heterogeneous computing. Computer Physics Communications. DOI: 10.1016/j.cpc.2015.06.010.
  8. (2014).Virtual screening with AutoDock Vina and the common pharmacophore engine of a low diversity library of fragments and hits against the three allosteric sites of HIV integrase: participation in the SAMPL4 protein–ligand binding challenge. Journal of Computer-Aided Molecular Design. DOI: 10.1007/s10822-014-9709-3.
  9. (2010).Fragment-Based Screen against HIV Protease. Chemical Biology & Drug Design. DOI: 10.1111/j.1747-0285.2009.00943.x.
  10. (2010).A Dynamic Model of HIV Integrase Inhibition and Drug Resistance. Journal of Molecular Biology. DOI: 10.1016/j.jmb.2010.01.033.
  11. (2010).Virtual Screening with AutoDock: Theory and Practice. Expert Opinion on Drug Discovery. DOI: 10.1517/17460441.2010.484460.
  12. (2009).AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. Journal of Computational Chemistry. DOI: 10.1002/jcc.21256.
  13. (2007).Analysis of HIV Wild-Type and Mutant Structures via in Silico Docking against Diverse Ligand Libraries. Journal of Chemical Information and Modeling. DOI: 10.1021/ci700044s.

GO Fight Against Malaria

  1. (2015).A Virtual Screen Discovers Novel, Fragment-Sized Inhibitors of Mycobacterium tuberculosis InhA. Journal of Chemical Information and Modeling. DOI: 10.1021/ci500672v.

Genome Comparison

  1. (2012).Design and Implementation of ProteinWorldDB. Advances in Bioinformatics and Computational Biology.
  2. (2010).ProteinWorldDB: querying radical pairwise alignments among protein sets from complete genomes. Bioinformatics. DOI: 10.1093/bioinformatics/btq011.

Help Conquer Cancer

  1. (2012).High-throughput protein crystallization on the World Community Grid and the GPU. Journal of Physics: Conference Series. DOI: 10.1088/1742-6596/341/1/012027.
  2. (2010).Protein crystallization analysis on the World Community Grid. Journal of Structural and Functional Genomics. DOI: 10.1007/s10969-009-9076-9.
  3. (2008).Establishing a training set through the visual analysis of crystallization trials. Part II: crystal examples. Acta Crystallographica Section D: Biological Crystallography. DOI: 10.1107/S0907444908028059.
  4. (2008).Establishing a training set through the visual analysis of crystallization trials. Part I: ~150 000 images. Acta Crystallographica Section D: Biological Crystallography. DOI: 10.1107/S0907444908028047.

Help Cure Muscular Dystrophy

  1. (2019).Decrypting protein surfaces by combining evolution, geometry, and molecular docking. Proteins: Structure, Function, and Bioinformatics. DOI: 10.1002/prot.25757.
  2. (2018).Hidden partners: Using cross-docking calculations to predict binding sites for proteins with multiple interactions. Proteins: Structure, Function, and Bioinformatics. DOI: 10.1002/prot.25506.
  3. (2017).Protein social behavior makes a stronger signal for partner identification than surface geometry. Proteins: Structure, Function, and Bioinformatics. DOI: 10.1002/prot.25206.
  4. (2016).Great interactions: How binding incorrect partners can teach us about protein recognition and function. Proteins: Structure, Function, and Bioinformatics. DOI: 10.1002/prot.25086.
  5. (2013).Protein-Protein Interactions in a Crowded Environment: An Analysis via Cross-Docking Simulations and Evolutionary Information. PLOS Computational Biology. DOI: 10.1371/journal.pcbi.1003369.
  6. (2009).From Dedicated Grid to Volunteer Grid: Large Scale Execution of a Bioinformatics Application. Journal of Grid Computing. DOI: 10.1007/s10723-009-9130-7.
  7. (2009).Joint Evolutionary Trees: A Large-Scale Method To Predict Protein Interfaces Based on Sequence Sampling. PLOS Computational Biology. DOI: 10.1371/journal.pcbi.1000267.
  8. (2008).Identification of Protein Interaction Partners and Protein–Protein Interaction Sites. Journal of Molecular Biology. DOI: 10.1016/j.jmb.2008.08.002.

Help Defeat Cancer

  1. (2011).ImageMiner: a software system for comparative analysis of tissue microarrays using content-based image retrieval, high-performance computing, and grid technology. Journal of the American Medical Informatics Association. DOI: 10.1136/amiajnl-2011-000170.
  2. (2010).Grid-Enabled, High-performance Microscopy Image Analysis.
  3. (2009).Virtual Microscopy and Grid-Enabled Decision Support for Large-Scale Analysis of Imaged Pathology Specimens. IEEE Transactions on Information Technology in Biomedicine. DOI: 10.1109/TITB.2009.2020159.
  4. (2009).PathMiner: A Web-Based Tool for Computer-Assisted Diagnostics in Pathology. IEEE Transactions on Information Technology in Biomedicine. DOI: 10.1109/TITB.2008.2008801.
  5. (2008).Therapeutic starvation and autophagy in prostate cancer: A new paradigm for targeting metabolism in cancer therapy. The Prostate. DOI: 10.1002/pros.20837.

Help Fight Childhood Cancer

  1. (2016).Effects of novel small compounds targeting TrkB on neuronal cell survival and depression-like behavior. Neurochemistry International. DOI: 10.1016/j.neuint.2016.04.017.
  2. (2014).Identification of novel candidate compounds targeting TrkB to induce apoptosis in neuroblastoma. Cancer Medicine. DOI: 10.1002/cam4.175.

Help Stop TB

  1. (2019).Revealing solvent-dependent folding behavior of mycolic acids from Mycobacterium tuberculosis by advanced simulation analysis. Journal of Molecular Modeling. DOI: 10.1007/s00894-019-3943-5.

Human Proteome Folding

  1. (2012).The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts. Molecular Cell. DOI: 10.1016/j.molcel.2012.05.021.
  2. (2012).The Plant Proteome Folding Project: Structure and Positive Selection in Plant Protein Families. Genome Biology and Evolution. DOI: 10.1093/gbe/evs015.
  3. (2011).The Proteome Folding Project: Proteome-scale prediction of structure and function. Genome Research. DOI: 10.1101/gr.121475.111.
  4. (2008).A Protein Domain-Based Interactome Network for C. elegans Early Embryogenesis. Cell. DOI: 10.1016/j.cell.2008.07.009.
  5. (2007).A Predictive Model for Transcriptional Control of Physiology in a Free Living Cell. Cell. DOI: 10.1016/j.cell.2007.10.053.
  6. (2007).Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS biology. DOI: 10.1371/journal.pbio.0050076.
  7. (2007).A conserved surface on Toll-like receptor 5 recognizes bacterial flagellin. Journal of Experimental Medicine. DOI: 10.1084/jem.20061400.
  8. (2007).BioNetBuilder: automatic integration of biological networks. Bioinformatics. DOI: 10.1093/bioinformatics/btl604.
  9. (2005).Genome-wide structural and functional protein characterization by ab initio protein structure prediction. Report / Department of Electrical Measurements. Lund Institute of Technology.

Mapping Cancer Markers

  1. (2026).IID 2025: Physical protein interaction data with detection types, co-purified protein sets, molecular docking, and immune cell networks. Nucleic Acids Research.
  2. (2022).IID 2021: towards context-specific protein interaction analyses by increased coverage, enhanced annotation and enrichment analysis. Nucleic Acids Research. DOI: 10.1093/nar/gkab1034.
  3. (2019).IID 2018 update: context-specific physical protein-protein interactions in human, model organisms and domesticated species. Nucleic Acids Research.
  4. (2016).Integrated Interactions Database: tissue-specific view of the human and model organism interactomes. Nucleic Acids Research.
  5. (2020).Informed Use of Protein-Protein Interaction Data: A Focus on the Integrated Interactions Database (IID). Methods in Molecular Biology.
  6. (2023).USNAP: fast unique dense region detection and its application to lung cancer. Bioinformatics. DOI: 10.1093/bioinformatics/btad477.
  7. (2015).Comparative network analysis via differential graphlet communities. Proteomics. DOI: 10.1002/pmic.201400233.
  8. (2019).Visualization of Biomedical Networks. Encyclopedia of Bioinformatics and Computational Biology.
  9. (2018).The ablation of the matricellular protein EMILIN2 causes defective vascularization due to impaired EGFR-dependent IL-8 production affecting tumor growth. Oncogene. DOI: 10.1038/s41388-017-0107-x.
  10. (2018).SDREGION: Fast Spotting of Changing Communities in Biological Networks. KDD '18: The 24th ACM SIGKDD International Conference on Knowledge Discovery and Data Mining. DOI: 10.1145/3219819.3219854.
  11. (2017).Network Motif Families for Lung Cancer Diagnostics: A World Community Grid Approach.
  12. (2015).Prioritizing Therapeutics for Lung Cancer: An Integrative Meta-analysis of Cancer Gene Signatures and Chemogenomic Data. PLOS Computational Biology. DOI: 10.1371/journal.pcbi.1004068.
  13. (2015).In silico prediction of physical protein interactions and characterization of interactome orphans. Nature Methods. DOI: 10.1038/nmeth.3178.

Microbiome Immunity Project

  1. (2023).Sequence-structure-function relationships in the microbial protein universe. Nature Communications. DOI: 10.1038/s41467-023-37896-w.

Nutritious Rice for the World

  1. (2016).Rice protein models from the Nutritious Rice for the World Project. biorxiv. DOI: 10.1101/091975.
  2. (2014).fast_protein_cluster: parallel and optimized clustering of large-scale protein modeling data. Bioinformatics. DOI: 10.1093/bioinformatics/btu098.
  3. (2012).Accelerated protein structure comparison using TM-score-GPU. Bioinformatics. DOI: 10.1093/bioinformatics/bts345.
  4. (2011).GPU-Q-J, a fast method for calculating root mean square deviation (RMSD) after optimal superposition. BMC Research Notes. DOI: 10.1186/1756-0500-4-97.

OpenZika

  1. (2022).Discovery of New Zika Protease and Polymerase Inhibitors through the Open Science Collaboration Project OpenZika. Journal of Chemical Information and Modeling. DOI: 10.1021/acs.jcim.2c00596.
  2. (2019).A diarylamine derived from anthranilic acid inhibits ZIKV replication. Scientific Reports. DOI: 10.1038/s41598-019-54169-z.
  3. (2019).High Throughput and Computational Repurposing for Neglected Diseases. Pharmaceutical Research. DOI: 10.1007/s11095-018-2558-3.
  4. (2018).Computational drug discovery for the Zika virus. Brazilian Journal of Pharmaceutical Sciences. DOI: 10.1590/s2175-97902018000001002.
  5. (2018).The A–Z of Zika drug discovery. Drug Discovery Today. DOI: 10.1016/j.drudis.2018.06.014.
  6. (2017).Molecular dynamics simulations of Zika virus NS3 helicase: Insights into RNA binding site activity. Biochemical and Biophysical Research Communications. DOI: 10.1016/j.bbrc.2017.03.070.
  7. (2016).OpenZika: An IBM World Community Grid Project to Accelerate Zika Virus Drug Discovery. PLOS Neglected Tropical Diseases. DOI: 10.1371/journal.pntd.0005023.
  8. (2016).Illustrating and homology modeling the proteins of the Zika virus. F1000Research. DOI: 10.12688/f1000research.8213.2.

The Clean Energy Project

  1. (2017).Design Principles and Top Non-Fullerene Acceptor Candidates for Organic Photovoltaics. Joule. DOI: 10.1016/j.joule.2017.10.006.
  2. (2015).What Is High-Throughput Virtual Screening? A Perspective from Organic Materials Discovery. Annual Review of Materials Research. DOI: 10.1146/annurev-matsci-070214-020823.
  3. (2015).Learning from the Harvard Clean Energy Project: The Use of Neural Networks to Accelerate Materials Discovery. Advanced Functional Materials. DOI: 10.1002/adfm.201501919.
  4. (2014).Lead candidates for high-performance organic photovoltaics from high-throughput quantum chemistry – the Harvard Clean Energy Project. Energy Environ. Sci.. DOI: 10.1039/C3EE42756K.
  5. (2011).Accelerated computational discovery of high-performance materials for organic photovoltaics by means of cheminformatics. Energy & Environmental Science. DOI: 10.1039/c1ee02056k.
  6. (2011).The Harvard Clean Energy Project: Large-Scale Computational Screening and Design of Organic Photovoltaics on the World Community Grid. The Journal of Physical Chemistry Letters. DOI: 10.1021/jz200866s.
  7. (2011).From computational discovery to experimental characterization of a high hole mobility organic crystal. Nature Communications. DOI: 10.1038/ncomms1451.

Other project-related publications

Mapping Cancer Markers (general lab output)

Other project-related publications

  1. 1.0 1.1 About Us. World Community Grid. Retrieved 2026-05-25.
  2. World Community Grid. Wikipedia. Retrieved 2026-05-25.
  3. World Community Grid – Smallpox precursor. Wikipedia. Retrieved 2026-05-25.
  4. 4.0 4.1 4.2 World Community Grid. HandWiki. Retrieved 2026-05-25.
  5. 5.0 5.1 5.2 5.3 Jurisica Lab – WCG. University of Toronto. Retrieved 2026-05-25.
  6. What is BOINC?. World Community Grid. Retrieved 2026-05-25.
  7. 7.00 7.01 7.02 7.03 7.04 7.05 7.06 7.07 7.08 7.09 7.10 World Community Grid. Wikipedia. Retrieved 2026-05-25.
  8. WCG Project Progress. BOINCStats. Retrieved 2026-05-25.
  9. World Community Grid BOINC. Medium. Retrieved 2026-05-25.
  10. 10.00 10.01 10.02 10.03 10.04 10.05 10.06 10.07 10.08 10.09 10.10 10.11 10.12 10.13 Completed Research. World Community Grid. Retrieved 2026-05-25.
  11. (2005-12-05).FightAIDS@Home joins World Community Grid. Scripps Research. Retrieved 2026-05-25.
  12. A Decade of Discovery. World Community Grid. Retrieved 2026-05-25.
  13. Ekins S, Perryman AL, Andrade CH.(2016-10-20).OpenZika: An IBM World Community Grid Project to Accelerate Zika Virus Drug Discovery. PLOS Neglected Tropical Diseases. pp. e0005023. DOI: 10.1371/journal.pntd.0005023.
  14. World Community Grid. IBM. Retrieved 2026-05-25.


See Also

References

External Links